Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-03-06
2000-12-19
Carlson, Karen Cochrane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530350, C07K 1400
Patent
active
061627852
ABSTRACT:
The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of the protein as well as biomedical uses are provided.
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Jose M.C. Ribeiro, Characterization of a Vasodilator from the Salivary Glands of the Yellow Fever Mosquito Aedes Aegypri, J. exp. Biol., 1992, 61-71, 165.
Jose M.C. Ribeiro and Roberto H. Nussenveig, The Salivary Catechol Oxidase/Peroxidase Activities of the Mosquito Anopheles Albimanus, J. exp. Biol., 1993, 273-287, 179.
Cross, et al., Differential Modulation of Murine Cellular Immune Responses by Salivary Gland Extract of Aedes Aegypri, Am. J. Trop. Med. Ilyg. 1994, 690-696, 51(5).
Cupp, et al., Vasodilative Activity in Black Fly Salivary Glands, Am. J. Trop. Med. Hyg., 1994, 241-246, 50(2).
Qureshi, et al., Immunomodulatory Properties of Maxadilan, the Vasodilator Peptide from Sand Fly Salivary Gland Extracts, 1996, Am. J. Trop. Med. Hyg., 1996, 665-671, 54(6).
Cupp, et al., Analysis of Black Fly Saliva and Its' Relationship to Vector Status, Abstract of oral presentation to the XY International Congress of Entomology, Sep. 1996, Firenze, Italiae.
Cupp Eddie W.
Cupp Mary S.
Ribeiro José M. C.
Swaim Steven F.
Auburn University
Carlson Karen Cochrane
University of Arizona
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