Recombinant varicella-zoster virus and process for constructing

Details Recombinant varicella-zoster virus and process for constructing Recombinant varicella-zoster virus and process for constructing

1997-03-13

1998-12-15

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 71, 530324, 530350, C12Q 170, G01N 3353, C07K 1402

Patent

active

058494766

ABSTRACT:
The present invention provides a recombinant varicella-zoster virus prepared by inserting, into the viral genome, nucleic acids from the hepatitis B virus genome, a genomic DNA of the recombinant varicella-zoster virus, a live vaccine containing the recombinant varicella-zoster virus as an effective ingredient, an antigen derived from the recombinant varicella-zoster virus, and diagnostic agent containing the antigen.
The recombinant varicella-zoster virus of the present invention can be utilized as a multivalent vaccine having an excellent immunity effect both on chicken pox and hepatitis B, and expression products and genomic DNA thereof may be used as a multivalent diagnostic agent.

REFERENCES:
patent: 4963483 (1990-10-01), Ellis et al.
Shiraki et al. "Processing of Hepatitis B Virus Surface Antigen Expressed Recombinant Oka Varicella Vaccine Virus", Journal of General Virology, vol. 73, pp. 1401-1407, 1992.
Shiraki et al., "Development of Immunogenic Recombinant Oka Varicella Vaccine Expressing Hepatitis B Virus Surface Antigen", Journal of General Virology, vol. 72, pp. 1393-1399, 1991.
Lowe et al., "Varicella-Zoster Virus as a Live Vector for the Expression of Foreign Genes", Proc. Natl. Acad. Sci., vol. 84, pp. 3896-3900, Jun. 1997.

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