Recombinant varicella-zoster virus and process for constructing

Details Recombinant varicella-zoster virus and process for constructing Recombinant varicella-zoster virus and process for constructing

1994-11-15

1997-08-05

Guzo, David

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 9141, 4351723, 4353201, 536 2372, A61K 3925, A61K 3929, C12N 1586

Patent

active

056539762

ABSTRACT:
The present invention provides a recombinant varicella-zoster virus prepared by inserting into the viral genome, nucleic acids from hepatitis B virus genome, a genomic DNA of the recombinant varicella-zoster virus, a live vaccine containing the recombinant varicella-zoster virus as an effective ingredient, an antigen derived from the recombinant varicella-zoster virus, and diagnostic agent containing the antigen. The recombinant varicella-zoster virus of the present invention can be utilized as a multivalent vaccine having an excellent immunity effect both on chickenpox and hepatitis B, and the expression products and genomic DNA thereof may be used as a multivalent diagnostic agent.

REFERENCES:
patent: 4963483 (1990-10-01), Ellis et al.
"Varicella-Zoster Virus as a Live Vector for the Expression of Foreign Ge, Lowe et al., PNAS, vol. 84, pp. 3896-3900, Jun. 1987.

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