Recombinant vaccine made in E. coli against dengue virus

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 79, 435 792, 435 691, 435975, 4241861, 4242181, 436536, 530350, 536 234, 536 2372, A61K 3912, C07H 2104, C07K 1418

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061176400

ABSTRACT:
A recombinant protein encompassing a C-terminal protion from the structural envelope glycoprotein and an N-terminal portion from non-structural protein one of dengue type 2 virus was expressed in Escherichia coli as a fusion protein with Staphylococcal protein A. The recombinant protein was found to provide protection against lethal challenge with dengue 2 in mice.

REFERENCES:
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Srivastava, A. K. et al. Mice immunized with dengue-2 virus E and NS-1 fusion protein are protected against lethal dengue virus infection. Abstract, 43rd Annual Meeting of the American Society of Tropical Medicine and Hygiene, Sep. 1994, 51:437.
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