Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1996-06-27
2000-07-11
Caputa, Anthony C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424 932, 4242561, 424825, 424932, 435243, 435245, 4352523, 4351723, 56 231, 56 2432, 56 2433, A61K 39102, C12N 136
Patent
active
060868945
ABSTRACT:
Vaccines for diseases caused by normally encapsulated organisms are produced by genetically modifying those organisms by deleting the genes encoding for capsule synthesis or a portion thereof sufficient to produce non-capsulated mutants of the organisms. As an example, a live, attenuated strain of Actinobacillus pleuropneumoniae genetically modified with a large deletion in a chromosomal regions of the DNA which encodes for capsule synthesis is a safe and effective vaccine against swine pleuropneumonia.
REFERENCES:
patent: 5429818 (1995-07-01), Inzana
Frosch et al. (1991) Mol. Microbiol. vol. 5(5), 1251-1263.
Ley et al (1995) Vaccine vol. 13(4), 401-107.
Kozel et al (1992) Infect. & Immunity vol. 60(8), 3122-3127.
Inzana Thomas J.
Ward Christine
Caputa Anthony C.
Masood Khalid
Virginia Tech Intellectual Properties Inc.
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