Recombinant vaccine against Lyme disease

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4242621, 4241841, 530350, 5303882, 5303884, 435 691, 435 693, A61K 3900, A61K 3902, C12P 2100, C07K 1600

Patent

active

055543715

ABSTRACT:
A highly-antigenic, recombinant polypeptide of a molecular weight of about 110-kD by SDS-PAGE is disclosed, which is derived by transforming E. coli with a 7.1 kB DNA fragment from EcoR1-digested B. burgdorferi DNA, followed by identification of cloned transformants expressing polypeptides which bind to anti-B. burgdorferi antibodies.

REFERENCES:
patent: 4721617 (1988-01-01), Johnson
Caputa Dissertation Abstracts International vol. 52/02-B Aug. 1991 Abstract only.
Caputa et al (Abstr.) Annual Meeting of Am. Soc for Microbiology May 1990 (Abst).
Anderson et al Annuls of the New York Academy of Sciences 539:181-191 1988.
A. G. Barbour et al., J. Clin. Invest., 72, 504 (1983).
S. Bergstrom, Mol. Microbiology, 4, 479 (1989).
R. Bey et al., Infect. Immunol., 19, 562 (1978).
M. Bradford, Anal. Biochem., 72, 248 (1976).
W. Burgdorfer et al., Science, 216, 1317 (1982).
I. Charles et al., PNAS USA, 86, 3554 (1989).
C. Collins et al., Infect. Immunol., 59, 519 (1991).
J. Craft et al., J. Infect. Dis., 149, 789 (1984).
E. Engvall et al., Immunochemistry, 8, 871 (1971).
E. Fikrig et al., Science, 250, 553 (1990).
L. Guo et al., Gene, 29, 251 (1984).
R. Grodzicki et al., J. Infect. Dis., 157, 790 (1988).
K. Hansen et al., Infect. Immunol., 56, 2047 (1988).
T. R. Howe et al., Infect. Immunol., 54, 207 (1985).
R. Johnson et al., Infect. Immunol., 53, 713 (1986).
R. Johnson et al., Infect. Immunol., 54, 897 (1986).
U. Laemmli et al., Nature, 227, 680 (1970).
K. Loken et al., Proc. Soc. Exp. Biol. Med., 179, 300 (1985).
L. Magnarelli et al., J. Clin. Microbiol., 20, 181 (1984).
L. Magnarelli et al. J. Infect. Dis., 156, 183 (1987).
H. Russell et al., J. Infect. Dis., 149, 465 (1984).
J. L. Schmidtz et al., Infect. Immunol., 58, 144 (1990).
R. Wallich et al. Infect. Immun., 58, 1711 (1990).
R. Young et al., PNAS USA, 80, 1194 (1983).
Philipp et al Inf & Immun. 61:3047-3059 1993 Early & Early Disseminated Phases of Lyme Disease in the Rhesus Monkey: A Model for Infection in Humans.
Fikrig et al I & I 60:773-777 1992.
Fikrig et al I & I 61:2553-2557, 1993.
Label for Borrelia burdorferi Bacterin, Fort Dodge Laboratories, Inc. (Sep. 7, 1990).
Szczepavski et al Microbiological Reviews 55:21-43 1991.
Edelman, Vaccine 9:531-532 1990.
Kanfor Scientific American Sep. 1994, pp. 34-39.
Caputa Dissertation, Abstract & pages.
Caputa ASM Abstract 1990.
Caputa et al, The Journal of Clinical Microbiology 29:2418-2423, 1991.
Schaible et al PNAS 84:3768-3772 1990.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Recombinant vaccine against Lyme disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant vaccine against Lyme disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant vaccine against Lyme disease will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1318752

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.