Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-11-21
1998-10-06
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241931, 42419611, 4242081, 435325, 435366, 435 693, 435 697, 530350, 530395, 530403, A61K 39385, C07K 1474
Patent
active
058173153
ABSTRACT:
A method for an induction of immune response against polypeptide employing antigenic presentation of said polypeptide in the form of either fusion protein with MHC product amino acid sequence or tertiary complex with MHC product on natural or artificial membrane, where said membrane may further either localize in internal compartment mediators of immune response or present membrane-bound form of said mediators on the surface of said membrane.
REFERENCES:
patent: 4400376 (1983-08-01), Sanderson
patent: 4478823 (1984-10-01), Sanderson
patent: 4861707 (1989-08-01), Ivanoff et al.
Allen, H., et al., Nature 309:279-281 (17 May 1984), "Domain interactions of H-2 class I antigens alter cytotoxic T-cell recognition sites."
Guillet, J-G., et al., Nature 324:260-262 (20 Nov. 1986), "Interaction of peptide antigens and class II major histocompatibility complex antigens".
Howard, J.C., et al. P.N.A.S. (USA) 90:3777-3779 (May, 1993), "Restrictions on the use of antigenic peptides by the immune system".
Sanderson, A. R., Nature 269:414-416 (1977), "HLA `help` for human B2-microglobulin across species barriers."
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