Recombinant tumor specific antibody and use thereof

Details Recombinant tumor specific antibody and use thereof Recombinant tumor specific antibody and use thereof

2005-07-01

2008-12-02

Rawlings, Stephen L (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S350000, C530S387700, C530S391700

Reexamination Certificate

active

07459538

ABSTRACT:
The invention provides a family of antibodies that specifically bind the human epithelial cell adhesion molecule. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies, when coupled to the appropriate moiety, may be used in the diagnosis, prognosis and treatment of cancer.

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