Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-04-04
1992-07-07
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530370, C12N 1529
Patent
active
051284600
ABSTRACT:
Disclosed are the entire protein and nucleic acid coding sequences for unprocessed and mature trichosanthin protein from Trichosanthes kirilowii. A recombinant trichosanthin protein produced from the coding sequence, and the trichosanthin protein with amino-terminal and/or carboxy-terminal extensions are also described. Primers derived from the coding sequence are disclosed for use in obtaining the coding sequences of ribosome-inactivating-proteins which have regions of amino acid sequence identical to those of trichosanthin. Further, a multigene family of ribosome-inactivating-protein encoding genes of Trichosanthes kirilowii is also described.
REFERENCES:
patent: 4459355 (1984-07-01), Cello et al.
patent: 4684611 (1987-08-01), Schilperoort et al.
patent: 4693976 (1987-09-01), Schilperoot et al.
patent: 4743548 (1988-05-01), Crossway et al.
patent: 4795739 (1989-01-01), Lifson et al.
patent: 4801540 (1989-01-01), Hiatt et al.
patent: 4869903 (1989-09-01), Lifson et al.
Collins et al., May 1990, J. Biol. Chem. 265(15):8665-8669.
Xuejun et al., 1986, Nature 321:477-478.
Tsao, S. W., et al., Toxicon 24(8):831 (1986).
Bonnerjea, J., et al., Bio/Technology 4:955 (1986).
Lee, C. C., et al., Science 239:1288 (1988).
Till, M. A., et al., Science 242:1166 (1988).
Gyllensten, U. B., et al., Proc. Natl. Acad. Sci. U.S.A. 85:7652 (1988).
Chow, T. P., et al., J. Biol. Chem. 265(15):8670 (1990).
Ready, M. P., et al., Proteins: Struct. Funct. Genet. 3(1):53 (1988).
Chaudhary, V. K., et al., Nature 335:369 (1988).
Wang, Q., et al., Shiyan Shengwu Xuebao 20(4):515 (1987)-Abstract from Chemical Abstracts.
Zi-Wei, G., et al., ACTA Chimica Sinica 42(9):943 (1984).
Yu, W., et al., Pure and Appl. Chem. 58(5):789 (1986).
Yeung, H. W., et al., Immunopharm. and Immunotox. 9(1):25 (1987).
Yeung, H. W., et al., Int. J. Pep. Prot. Res. 27:325 (1986).
Casellas, P., et al., Eur. J. Biochem. 176, 581-588 (1988).
Maraganore, J. M., et al., J. Biol. Chem. 262(24) 11628-11633 (1987).
McGrath, M. S., et al., Proc. Natl. Acad. Sci. U.S.A. 86 2844-2848.
Rogers, S. G., et al., Methods in Enzymology 153 253-276 (1987).
Sela, I., Methods in Enzymology 119 734-745 (1986).
Deblaere, R., et al., Methods in Enzymology 153 277-292 (1987).
Weising, K., et al., Annu. Rev. Genet. 22 421-477 (1988).
Benfey, P. N., et al., Science 244 174-181 (1989).
Abel, P. P. et al., Science 232 738-743 (1986).
Vaeck, M., et al., Nature 328, 33-37 (1987).
Fassuliotis, G., Chapter 48 in Vistas on Nematology, edited by J. A. Veech et al., (1987).
Yeung, H. W., et al., Immunopharmacology and Immunotocixology, 9(1) 24-46 (1987).
Chow Theresa P.
Fry Kirk
Piatak, Jr. Michael
Dehlinger Peter J.
Fabian Gary R.
Furman Keith C.
Genelabs Incorporated
Wax Robert A.
LandOfFree
Recombinant trichosanthin and coding sequence does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant trichosanthin and coding sequence, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant trichosanthin and coding sequence will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1831017