Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-12-28
1999-11-16
Sisson, Bradley
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 514 6, 514 12, C07K 1479, A61K 3840
Patent
active
059860677
ABSTRACT:
Recombinant transferrin, non-glycosylated recombinant transferrin, transferrin half-molecules and mutant transferrins having altered metal-binding or other properties are described. The recombinant transferrin molecules are expressed in functional form by stable eukaryotic cell lines such as baby hamster kidney cells transformed with an expression vector encoding the recombinant molecule. The recombinant transferrins can be used in metal chelation therapy to bind and clear excess toxic metals in patients suffering from metal overloads or as tissue culture medium supplements or replacements.
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Funk Walter D.
MacGillivray Ross T. A.
Mason Anne B.
Woodworth Robert C.
Bugaisky Gabriele E.
DeConti, Jr. Giulio A.
Sisson Bradley
The University of British Columbia
The University of Vermont and State Agricultural College
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