Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-05-09
1998-09-22
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241991, 4241861, 4242041, 4353201, 435 693, A61K 39215, A61K 3912, C12N 1500, C12N 1509
Patent
active
058111042
ABSTRACT:
The present invention relates to the development of an efficacious vaccine against Feline Infectious Peritonitis Virus (FIPV). The invention provides the tools for the synthesis and manipulation of the structural and non-structural proteins of FIPV. These proteins are able to elicit an immune response in cats against FIPV. The recombinant virus vectors which express the E1 or N proteins of the virus or the recombinant produced viral proteins themselves are able to elicit an immune response.
REFERENCES:
August et al., "Feline Infectious Peritonitis", Vet Clin North Am: Anim Pract 14(5):975-984 (1984).
Barlough et al., "Feline Infectious Peritonitis", Churchhill Livingstone, New York, Infectious Diseases 3:93-108 (1986).
Barlough et al., "Experimental Inoculation of Cats with Canine Coronavirus and Subsequent Challenge with Feline Infectious Peritonitis Virus", Lab Anim Sci 34(6):592-597 (1984).
Woods et al., "Cross-Protection Studies Between Feline Infectious Peritonitis and Porcine Transmissible Gastroenteritis Viruses", Vet Microbiol 4:11-16 (1979).
Pedersen et al., "Attempted Immunization of Cats Against Feline Infectious Peritonitis, Using Avirulent Live Virus of Sublethal Amounts of Virulent Virus", Am J Vet Res 44(2):229-234 (1983).
Pederson et al., "Experimental Studies with Three New Strains of Feline Infectious Peritonitis Virus: FIPV-UCD2, FiPV-UCD3, and FIPV-UCD4",Compendium on Continuing Education for the Practicing Veterinarian 7:1001-1011 (1985).
De Groot et al., "cDNA Cloning and Sequence Analysis of the Gene Encoding the Peplomer Protein of Feline Infectious Peritonitis Virus", J Gen Virol 68:2639-2646 (1987).
R. J. DeGroot et al., "Sequence Analysis of the 3' End of the Feline Coronavirus FIPV 79-1146 Genome: Comparison with the Genome of Porcine Coronavirus TGEV Reveals Large Insertions", Virology 167:370-376 (1988).
R. J. DeGroot et al., "Intracellular RNAs of the Feline Infectious Peritonitis Coronavirus Strain 79-1146", J Gen Virol 68:995-1002 (1987).
S. A. Fiscus et al., "Competitive Enzyme Immunoassays for the Rapid Detection of Antibodies to Feline Infections Peritonits Virus Polypeptides", Biological Abstracts, vol. 80, Abstract No. 104471 (1985).
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Vennema et al. "Primary Structure of the Membrane and Nucleocapsid protein Genes of Feline Infectious Peritonitis and Immunogenicity of Recombinant Vaccinia Viruses Kittens". Virology. Vol. 181:327-335, 1991.
Wasmoen et al. "Protection of Cats From Infectious Peritonitis By Vaccination With a Recombinant Raccoon Poxvirus Expressing The Nucleocapsid Gene of Feline Infectious Peritonitis Virus". Corona and Related Viruses. Talbot et al, Eds. Plenum Press, Ny, pa, 1995.
Mackett et al. "Vaccinia Virus Expression Vectors". Journal of General Virology. Vol. 67, No. 10:2067-2082, 1986.
Kapke et al. "Nucleotide Sequence of the Porcine Transmissible Gastroenteritis Coronavirus Matrix Protein Gene". Adv. Exp. Med. Biol. vol. 218:117-122, 1987.
deGroot et al. "Intracellular RNAs of the Feline Infectious Coronavirus Strain 79-1146". Journal of General Virology. Vol. 68:995-1002, 1987a.
deGroot et al. "cDNA Cloning and sequence Analysis of the Gene Encoding the Peplomer Protein of Feline Infectious Peritonitis Virus". Journal of General Virology. Vol. 68:2639-2646, 1987b.
Lapps et al. "Sequence Analysis of the Bovine Coronavirus Nucleocapsid and Matrix protein Genes". Virology. Vol. 157: 47-57, 1987.
Rasschaert et al. "Enteric coronavirus TGEV: partial sequence of the genomic RNA, its organization and expression". Biochimie. Vol. 69:591-600, 1987.
Tomley et al. "Expression of the Infectious Bronchitis Virus Spike Protein by Recombinant Vaccinia Virus and Induction of Neutralizing Antibodies in Vaccinated Mice". Journal of General Virology. Vol. 68:2291-2298, 1987.
Ellis, Ronald. "New Technologies for Making Vaccines". Plotkin et al, Eds. Chapter 29, pp. 568-575, 1988.
Acree William M.
Chavez, Jr. Lloyd G.
Dale Beverly
Yamanaka Miles
American Home Products Corporation
Knode Marian C.
Lee Datquan
Scios Inc.
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