Recombinant sequence, its preparation and use

Details Recombinant sequence, its preparation and use Recombinant sequence, its preparation and use

2007-07-24

2007-07-24

Priebe, Scott D. (Department: 1633)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S325000, C435S243000, C435S320100, C514S04400A

Reexamination Certificate

active

10275296

ABSTRACT:
An isolated, purified or recombinant nucleic acid sequence is disclosed, comprising: (a) a sequence that encodes both an angiogenic factor antagonist and a vascular endothelial structure regulator; (b) a sequence substantially homologous to or that hybridizes to sequence (a) under stringent conditions; or (c) a sequence substantially homologous to or that hybridizes under stringent conditions to the sequence (a) or (b) but for the degeneracy of the genetic code; or (g) an oligonucleotide specific for any of the sequences (a), (b) or (c). Particular oligonucleotides (d) are those encoding the vascular endothelial structure regulator. Also described are methods for preparing the recombinant polynucleotide, proteins encoded by such polynucleotides and their use in gene or protein therapy for the treatment of conditions such as cancer.

REFERENCES:
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