Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1987-03-12
1992-01-07
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, 530396, C12N 121, C12N 1570, C07K 1300
Patent
active
050791630
ABSTRACT:
Ricin B muteins, ricin and ricin precursors having at least one amino acid of at least one galactoside binding site altered to decrease the binding of ricin B to galactosides are claimed. DNA sequences encoding the ricin B muteins, ricin and ricin precursor in which the B chain thereof is the ricin B mutein are claimed. Recombinant expression vectors effective in expressing the DNA sequences of the ricin B muteins, ricin and ricin precursors are claimed. Host cells transformed with the foregoing expression vectors are also claimed. Conjugates comprising binding moieties such as antibodies, hormones, and lymphokines bound to the ricin B mutein and ricin wherein the B chain thereof is the mutein is also claimed.
REFERENCES:
Wawrzynczak, E. J. et al, Feb. 22, 1986, J. Cell. Bioch. 10B: p. 71.
Robertus, J. D. et al, Jan. 5, 1987, J. B.C. 262(1), 19-20.
Lamb, F. I. et al, 1985, Eur. J. Biochem. 148:265-270.
Zoller, M. J. and Smith, M., 1984, DNA 3(6), 479-488.
Mise, T. et al, 1986, Agric. Biol. Chem. 50(1), 151-155.
Zoller, M. J. and Smith, M., 1982, Nucl. Acids Res. 10(20), 6487-6500.
Montfort, W. et al., Apr. 15, 1987, J. B.C. 262(11), 5398-5403.
Rutenber, E. et al, 1987 (Apr. 9), Nature 326:1624-1626.
Ladin, B. F. et al., 1987, Plant Molecular Biology, 9:287-295.
Halling, K. C., et al., 1985, Nucleic Acids Research, 13 (22):8019-8032.
Emerick Anne W.
Houston L. L.
Piatak, Jr. Michael
Cetus Corporation
Fineman Elliott
Giotta Gregory J.
Halluin Albert P.
Schwartz Richard A.
LandOfFree
Recombinant ricin toxin fragments does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant ricin toxin fragments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant ricin toxin fragments will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-821939