Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1995-06-07
1998-12-22
Elliott, George C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242771, 424 932, A61K 3921, A61K 3900, A61K 4800
Patent
active
058515291
ABSTRACT:
Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
REFERENCES:
patent: 4405712 (1983-09-01), Vande Woude et al.
patent: 4650764 (1987-03-01), Temin et al.
patent: 4663281 (1987-05-01), Gillies et al.
patent: 4708818 (1987-11-01), Montagnier et al.
patent: 4725669 (1988-02-01), Essex et al.
patent: 4738922 (1988-04-01), Haseltine et al.
patent: 4861719 (1989-08-01), Miller
patent: 4868116 (1989-09-01), Morgan et al.
patent: 4980286 (1990-12-01), Morgan et al.
patent: 4980289 (1990-12-01), Temin et al.
patent: 5026635 (1991-06-01), Ferguson et al.
patent: 5192553 (1993-03-01), Boyse et al.
patent: 5246924 (1993-09-01), Fox et al.
patent: 5304489 (1994-04-01), Rosen
patent: 5306631 (1994-04-01), Harrison et al.
patent: 5399346 (1995-03-01), Anderson et al.
Bachmann et al. (1994) Curr. Opin. Immunol. 6:320-326.
Adam et al., J. Virology, 62(10):3802-3806, 1988.
Anderson F.W., Science, 256:808-813, 1992.
Arnold et al., J. Cell. Biochem., L401:145, 1990.
Baltimore, Nature, 335:395-396, 1988.
Besnard, et al., Molecular and Cell Biology, 7:4139-4141, 1987.
Borrelli, et al., Proc. Natl. Acad. Sci., 85:7572-7576, 1988.
Buseyne et al., J. Immunology, 150(8):3569-3581, 1993.
Carmichael et al., J. Exp. Med., 177:249-256, 1993.
Chada et al., J. Virol. 67(6):3409-3417, 1993.
Cepko et al., Cell, 37:1053-1062, 1984.
Cone et al., Mol. & Cell. Biol, 7(2):887-897, 1987.
Cournoyer et al., Ann. Rev. Immunol.,11:297-329, 1993.
Czarniecki et al., J. of Virology, 49(2):490-496, 1984.
Dadaglio et al., Clin. Ex. Immunol., 87:7-14, 1992.
Danos et al., Proc. Nat'l Acad. Sci., 85:6460-6464, 1988.
Davison et al., J. Gen. Virol., 67:1759-1816, 1986.
Dayton et al., Cell, 44:941-947, 1986.
De Baetselier et al., Nature, 288:179-181, 1980.
Deen et al., Nature, 331:82-84, 1988.
Doherty et al., J. Inf. Disease, 159(6):1119-1122, 1989.
Ellrodt et al., Nature, 325:765, 1987.
Fauci et al., Ann. Intern. Med., 110:373-385, 1989.
Dzierzak et al., Nature, 331:35-41, 1988.
Felber et al., Science, 239:184-187, 1988.
Felgner et al., Proc. Nat'l Acad. Sci., 84:7413-7417, 1987.
Fisher-Hoch et al., Proc. Nat'l Acad. Sci., 86:317-321, 1989.
Frankel et al., Proc. Nat'l Acad. Sci., 85:6297-6300, 1988.
Frankel et al., Science, 240:70-73, 1988.
Friedman et al., Nature, 335:452-454, 1988.
Furman et al., J. Virology, 32(1):72-77, 1979.
Ganz et al., J. Clin. Invest., 76:1427-1435, 1985.
Goelz, S.E., Science, 228:187-190, 1985.
Graham et al., J. Virology, 52:456-467, 1973.
Guild et al., J. Virol., 62(10):3795-3801, 1988.
Harrison et al., J. Cell. Biochem., Supp. 13B:302 (Abstract G418) 1989.
Haynes, B.F., Science, 260:1279-1286, 1993.
Hirsch, M.S., J. Infect. Dis., 157(3):427-431, 1988.
Ho et al., Proc. Nat'l Acad. Sci., 86:6714-6718, 1989.
Holt et al., Proc. Nat'l Acad. Sci., 83:4794-4798, 1986.
Howell et al., Mol. Biol. Med., 4:157-168, 1987.
Hu et al., Nature, 328:721-723, 1987.
Hussey et al., Nature, 331:78-81, 1988.
Izant et al., Science, 229:345-352, 1985.
Johnston et al., Science, 260:1286-1293, 1993.
Joly et al., J. Immunol., 143(7):2193-2201, 1989.
Kantoff et al., Proc. Nat'l Acad. Sci., 83:6563-6567, 1986.
Katoh et al., Nature, 329:654-656, 1987.
Kriegler et al., Cell, 38:483-491, 1984.
Kuriyama, et al., Cell Structure and Function, 16:503-510, 1991.
Kuriyama, et al., Intl. Hepatology Communications, 1:253-259, 1993.
Lathe et al., Nature, 326:878-880, 1987.
Lang et al., Cell, 43:531-542, 1985.
Ledley et al., Proc. Nat'l Acad. Sci., 83:409-413, 1986.
Lotze et al., Immunology, 11:190-193, 1990.
Malim et al., Nature, 338:254-257, 1989.
Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor Press, pp. 22-26, 1982.
Maniatis et al., Science, 236:1237-1245, 1987.
Mansour et al., Nature, 336:348-352, 1988.
Mariman, E.C.M., Nature, 318:414, 1985.
Maxwell et al., Cancer Research, 46:4660-4664, 1986.
Maxwell et al., J. Cell. Biochem., Supp. 10D:39 (Abstract N93)1986.
Maxwell et al., J. Cell. Biochem., Supp. 11D:67 (Abstract P314) 1987.
McCormick, D., BioTechnology, 3(8):689-693, 1985.
McCune et al., Cell, 53:55-67, 1988.
Mercola et al., Science, 208:1033-1035, 1980.
Miedema et al., J. Cell. Biochem., Supp. 17D:75 (Abstract N350), 1993.
Miller et al., Mol. Cell. Biol., 6(8):2895-2902, 1986.
Mitsuya et al., Nature, 325:773-778, 1987.
Moolten, F.L., Medical Hypothese, 24:43-51, 1987.
Moolten, F.L., Cancer Research, 46:5276-5281, 1986.
Mosier et al., Proc. Nat'l Acad. Sci., 90:2443-2447, 1993.
Muesing et al., Cell, 48:691-701, 1987.
Mulligan, R.C., Exper. Manip. of Gene Expression, 8:155-173, 1983.
Nabel et al., Science, 239:1299-1302, 1988.
Nelson, et al., Cold Spring Harbor Laboratory, LI:1065-1071, 1986.
Newell et al., J. Virol., 63(2):769-775, 1989.
Overhauser et al., J. Virol., 54(1):133-144, 1985.
Palmiter et al., Cell, 80:435-443, 1987.
Patarca et al., Proc. Nat'l Acad. Sci., 85:2733-2737, 1988.
Peterlin et al., Proc. Nat'l Acad. Sci., 83:9734-9738, 1986.
Phelps et al., Cell, 53:539-547, 1988.
Piatak et al., J. Biol. Chem., 263(10):4837-4843, 1988.
Pizer, et al., Intl. J. Cancer, 40:114-121, 1987.
Rein et al., Proc. Nat'l Acad. Sci., 83:7246-7250, 1986.
Salk, J. Nature, 327:473-476, 1987.
Selsted et al., J. Clin. Invest., 76:1436-1439, 1985.
Shinitzky et al., EORTC Gentitourinary Group Monograph Basic Research and Treatment of Renal Cell Carcinoma Metastasis, 9:95-125, 1990.
Shinnick et al., Nature, 293:543-548, 1981.
Smith et al., Science, 238:1704-1707, 1987.
Sleckman et al., Nature, 328:351-353, 1987.
Sodroski et al., Science, 22:171-173, 1985.
Sodroski et al., Science, 229:74-77, 1985.
Stratowa et al., EMBO J., 1(12):1573-1578, 1982.
Strebel et al., Nature, 358:728-730, 1987.
Tabin et al., Mol. & Cell. Biology, 2(4):426-436, 1982.
Tellier et al., Nature, 318:414, 1985.
Temin, H.M., In: Gene Transfer, Kucherlapati (Ed.),Plenum Press, New York, pp. 149-187, 1986.
Temin, H.M., Science, 246:983, 1989.
Torpey, III et al., Clinical Immunol. & Immunopath., 68(5):263-272, 1993.
Treisman, Cell, 46:567-574, 1986.
Trucco, M., Clin. Investig., 70:756-765, 1992.
Van Beveran et al., Cell, 27:97-108, 1981.
Verma et al., In: Eurkaryotic Viral Vectors, Gluzman, Y. (Ed.), Cold Spring Harbor Laboratory, pp. 159-164, 1982.
Voss et al., J. Gen. Virology, 73:2273-2281, 1992.
Wachsman et al., Science, 235:674-677, 1987.
Walbot et al., Nature, 334:196-197, 1988.
Wasmoen et al., J. Biol. Chem., 263:12559-12563, 1988.
Yasutomi et al., J. Virol., 67(3):1707-1711, 1993.
Yee et al., Proc. Nat'l Acad. Sci., 84:5197-5201, 1987.
Yu et al., Proc. Nat'l Acad. Sci., 83:3194-3198, 1986.
Zagury et al., Nature, 326:249-250, 1987.
Greenough et al., "Normal Immune Function and Inability to Isolate Virus in Culture in an Individual with Long-Term Human Immunodeficiency Virus Type 1 Infection" Aids Research and Human Retroviruses 10(4):395-403, 1994.
Irwin et al., "Direct Injection of a Recombinant Retroviral Vector Induces Human Immunodeficiency Virus-Specific Immune Responses in Mice and Nonhuman Primates" J. Virology 68(8):5036-5044, Aug., 1994.
Koup et al., "Temporal Association of Cellular Immune Responses with the Initial Control of Viremia in Primary Human Immunodeficiency Virus Type 1 Syndrome" J. Virology 68(7):4650-4655, Jul., 1994.
Koup and Ho, "Shutting Down HIV" Nature 370:416, Aug., 1994.
Lieberman et al., "Immunotherapy with Autologous Expanded HIV-Specific Cytotoxic T Cells in Inf
Guber Harry E.
Jolly Douglas J.
Laikind Paul K.
Respess James G.
Blackburn Robert P.
Elliott George C.
Kruse Norman J.
Schwartzman Robert
LandOfFree
Recombinant retroviruses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant retroviruses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant retroviruses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2043309