Recombinant raccoon pox viruses and their use as an effective va

Details Recombinant raccoon pox viruses and their use as an effective va Recombinant raccoon pox viruses and their use as an effective va

1998-01-15

1999-11-23

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

514 44, 4242081, A61K 3912, A61K 3921, A01N 4304

Patent

active

059895624

ABSTRACT:
The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the invention have at least one internal gene comprising a DNA sequence that encodes FIV gag protein (gag), FIV envelope protein (env), a polypeptide consisting of amino acids 1-735 of FIV env, or immunogenic fragments of any of the foregoing. The vaccines that comprise one or more of the FIV-expressing recombinant raccoon poxviruses described above may also comprise a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. The invention also provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.

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