Recombinant pseudomonas exotoxins: construction of an active imm

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 694, 435 6952, 435 696, 435 697, 424 8591, 424 88, 424 92, 424 915, 530350, 530351, 530370, 530395, 530396, 935 14, 935 29, 935 56, 935 60, 935 65, 514 2, 514 6, 514 12, C12P 2100, C12P 2102, C12N 910, A61K 3400

Patent

active

048928275

ABSTRACT:
Modified Pseudomonas exotaxins which comprise deletions in at least domain 1A are taught. The toxins exhibit reduced cytotoxicity.

REFERENCES:
patent: 4545985 (1983-10-01), Pastan et al.
Allured et al. Proc Natl Acad Sci vol. 83, pp. 1320-Mar. 1986, "Structure of exotoxin A of Pseudomonas aeruginousa at 3.0-Angstrom resolution".
Fitzgerald et al Proc Natl. Acad Sci vol. 80, pp. 4134-4138, Jul. 1983 "Enhancement of toxicity of antitransferrin receptor antibody Pseudomonas exotoxin conjugates by adenovirus".
Gray et al. Proc Natl Acad Sci May 1984 vol. 81, pp. 2645-2649 "Cloningt, nucleotide sequence, and expression in Escherichia coli of the exotoxin A structural gene of Pseudomonas aeruginosa".
Hwang et al. Cell vol. 48, pp. 129-136, Jan. 16, 1987, "Functional Domains of Pseudomonas Exotoxin Identified by Deletion Analysis of the Gene Expressed in E. Coli".
Kondo et al, 1988, Journal Biol. Chem. 263:9470-75.
Jinno et al, 1988, J. Biol. Chem. 263:13203-207.
Wozniak et al, 1988, PNAS, U.S.A. 85:8880-8884.
Chaudhary et al, 1988, PNAS, U.S.A. 85:2939-2943.
Montfont et al, 1987, J. Biol. Chem. 262:5398-5403.
Ribi et al, 1988, Science, 239:1272-1276.
Brandhuber et al, 1987, Science, 238:1707-1709.
Brandhuber et al, 1988, Proteins . . . 3:146-154.
McKay et al, 1982, J. Biol. Chem, 257:9518-24.
Weber et al, 1987, J. Mol. Biol. 198:311-326.
Bennett et al, 1978, PNAS, U.S.A. 75:4848-52.
Almassy et al, 1986, Nature, 323:304-309.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Recombinant pseudomonas exotoxins: construction of an active imm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Recombinant pseudomonas exotoxins: construction of an active imm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant pseudomonas exotoxins: construction of an active imm will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-145304

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.