Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-03-15
1997-02-11
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 530403, 530825, 530350, 530351, 4353201, 4351723, 43525233, 4352523, 435 691, 435 693, 435 697, 930200, 4241921, 4241931, 4242361, C07K 1421
Patent
active
056020953
ABSTRACT:
This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.
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Fitzgerald David J.
Pastan Ira H.
Low Christopher S. F.
The United States of America as represented by the Secretary of
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