Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1995-06-05
1998-10-13
Feisee, Lila
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241791, 4241831, 424832, 435 697, 4351723, 530350, 5303871, 5303877, 5303873, 5303917, 530825, 514 12, A61K 39104, A61K 3843, C07K 1421, C12P 2102
Patent
active
058212388
ABSTRACT:
This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.
REFERENCES:
patent: 4892827 (1990-01-01), Pastan et al.
patent: 5082927 (1992-01-01), Pastan et al.
Kreitman RJ et al (1994) Biochemistry 33:11637-11644.
Chaudhary et al., Proc. Natl. Acad. Sci. USA, 84:4538-4542 (1987).
Chaudhary et al., Proc. Natl. Acad. Sci. USA, 85:2939-2943 (1988).
Siegall, C.B. et al., "Functional Analysis of Domains II, Ib, and III of Pseudomonas Exotoxin", Journal of Biological Chemistry, 264:14256-14261 (1989).
Lorberboum-Galski, H. et al., "IL2-PE66.sup.4Glu, a New Chimeric Protein cytotoxic to Human-activated T Lymphocytes", Journal of Biological Chemistry, 265:16311-16317 (1990).
Heimbrook, D.C. et al., "Transforming growth factor .alpha.-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts", Proc. Natl. Acad. Sci. USA, 87:4697-4701 (1990).
Chaudhary et al., Proc. Natl. Acad. Sci. USA, 87:308-312 (1990).
Seetharam, S. et al., "Increased Cytotoxic Activity of Pseudomonas Exotoxin and Two Chimeric Toxins Ending in KDEL", Journal of Biological Chemistry, 266:17376-17381 (1991).
Kreitman, R.J. et al., "Properties of Chimeric Toxins with Two Recognition Domains: Interleukin 6 and Transforming Growth Factor .alpha. at Different Locations in Pseudomonas Exotoxin", Bioconjugate Chemistry, pp. 63-68 (1992).
Kreitman, R.J. et al., "Rational Design Of A Chimeric Toxin: An Intramolecular Location for the Insertion of Transforming Growth Factor .alpha. within Pseudomonas Exotoxin as a Targeting Ligand", Bioconjugate Chemistry, pp. 58-62 (1992).
Pastan et al., Science 254:1173-1177 (1991).
Theuer et al., J. Biol. Chem. 267:16872-16877 (1992).
Watson et al. 1987 in Molecular Biology of the Gene, Fourth Edition, Benjamin/Cummings Publishing Company, Inc. p. 313.
Siegall et al. 1991 Biochem. 30, 7154-7159.
Gray et al. 1984. Proc. Nat'l. Acad. Sci. USA 81, 2645-2649.
Ogata et al. 1990 J. Biol. Chem. 265, 20678-20685.
Jinno et al. 1989 J. Biol. Chem. 264, 15453-15959.
Fitzgerald David J.
Pastan Ira H.
Feisee Lila
Lucas John
The United States of America as represented by the Department of
LandOfFree
Recombinant pseudomonas exotoxin with increased activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant pseudomonas exotoxin with increased activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant pseudomonas exotoxin with increased activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-313375