Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1996-04-08
1999-03-30
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242011, 4241981, 4242041, 4242781, 4241991, 424815, 4352351, 435 5, 435 693, 435325, 4352523, 435 911, 435239, 530350, 536 2372, A61K 3900, A61K 3912, C12N 1500, C12N 700
Patent
active
058885137
ABSTRACT:
Recombinant proteins of the causative virus of porcine reproductive and respiratory syndrome (PRRS), corresponding to ORFs 2 to 7 of the PRRSV Spanish isolate (PRRS-Olot), have been produced in baculovirus expression system using Sf9 cell cultures as a permissive host. These recombinant proteins are suitable for the formulation of vaccines capable of efficaciously protecting porcine livestock from PRRS and for the preparation of diagnostic kits adequate for detection of anti-PRRSV antibodies as well as of PRRSV in a pig biological sample. This invention is of interest to Veterinary Medicine.
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von V.F. Ohlinger, et al., Der Seuchenhafte Spatabort beim Schwein--Ein Beitrag zur Atiologie des Porcine Reproductive and Respiratory Syndrome (PRRS), Tierarztl. Umschau 46, 703-708 (1991).
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C. Terpstra, et al., Experimental reproduction of porcine epidemic abortion and respiratory syndrome (mystery swine disease) by infection with Lelystad virus: Koch's postulates fulfilled, The Veterinary Quarterly, vol. 13, No. 3, 1991, 131-136.
J.M.A. Pol, et al., Pathological, ultrastructural, and immunohistochemical changes caused by Lelystad virus in experimentally induced infections of mystery swine disease (synonym: porcine epidemic abortion and respiratory syndrome (PEARS)), The Veterinary Quarterly, vol. 13, No. 3, 137-143 (Jul. 1991).
D.J. Paton, et al., Isolation of a Lelystad virus-like agent from British pigs and scanning electron microscopy of infected macrophages, Veterinary Microbiology, 33 (1992), 195-201.
Joan Plana, et al., Porcine epidemic abortion and respiratory syndrome (mystery swine disease). Isolation in Spain of the causative agent experimental reproduction of the disease, Veterinary Microbiology 33 (1992) 203-211.
Alvarez Jose Ignacio Casal
Climent Sanchez Isabel
Duran Juan Plana
Cepeda Milagros A.
Cyanamid Iberica, S.A.
Matthews Gale
Mosher Mary E.
Salimi Ali R.
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