Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-04-11
2000-04-25
Eisenschenk, Frank C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 5, 435 71, 4353201, 4352402, 4352523, 4352542, 435 691, C12N 1511, C12N 1563, C12N 1500, C12Q 170
Patent
active
060545674
ABSTRACT:
The invention relates to the expression of open reading frame 2 (ORF-2) proteins of a strain of hepatitis E virus from Pakistan (SAR-55) in a eukaryotic expression system. The expressed proteins can serve as an antigen in diagnostic immunoassays and/or as an immunogen or vaccine to protect against infection by hepatitis E.
REFERENCES:
patent: 5686239 (1997-11-01), Reyes et al.
patent: 5741490 (1998-04-01), Reyes et al.
patent: 5770689 (1998-06-01), Reyes et al.
Tsarev et al. Jan. 1992 PNAS USA 89 p559-563.
He et al. Jan. 1993 J Clin Microbiol. 31 p2167-2173.
Li et al. Sep. 1994 J Clin Microbiol. 32 (9) 2060-2066.
He et al. Dec. 1995 J Clin Microbiol. 33 (12) 3308-3311.
Panda et al. Oct. 1995 J Clin Microbiol. 33 (10) 2653-2659.
Dawson et al., "Solid-Phase Enzyme-Linked Immunosorbent Assay For Hepatitis E Virus IgG and IgM Antibodies Utilizing Recombinant Antigens And Synthetic Peptides," J. Virol. Methods, 38:175-186 (1992).
Uchida et al., "Hepatitis E Virus: cDNA Cloning and Expression," Microbiol, Immunol.,36:67-79 (1992).
Skidmore et al., "Hepatitis E Virus: The Cause Of A Waterbourne Hepatitis Outbreak," J. Med. Virol,. 37:58-60 (1992).
Saeed et al., "Elisa For Diagnosis Of Acute Sporadic Hepatitis E," Lancet, 339:882 (1992).
Aye et al., "Complete Nucleotide Sequence Of A Hepatitis E Virus Isolated From The Xinjiang Epidemic (1986-1988) Of China," Nucleic Acids Res., 20:3512 (1992).
Hyams et al., "Acute Sporadic Hepatitis E In Sudanese Children: Analysis Based On A New Western Blot Assay," J. Infect. Dis., 165:1001-1005 (1992).
Tsarev et al., "Characterization Of A Prototype Strain Of Hepatitis E Virus," Proc. Nat. Acad. Sci., 89;559-563 (1992).
Yarbough et al., "Hepatitis E Virus: Identification Of Type-Common Epitopes," J. Virol., 65:5790-5797 (1992).
Ichikawa et al., "Cloning and Expression of cDNAs From Enterically-Transmitted Non-A, Non-B Hepatitis Virus," Microbiol. Immunol., 35:535-543 (1992).
Purdy et al., "Expression Of A Hepatitis E Virus (HEV)-trpE Fusion Protein Containing Epitopes Recognized By Antibodies In Sera From Human Cases And Experimentally Infected Primates," Archives Virol., 123:335-349 (1992).
Favorov et al., Serologic Identification Of Hepatitis E Virus Infections In Epidemic And Endemic Settings, J. Med. Virol., 36:246-250 (1992).
Reyes et al., "Isolation Of A cDNA From The Virus Responsible For Enterically Transmitted Non-A, Non-B Hepatitis," Science, 247:1335-1339 (1992).
Tam et al., "Hepatitis E Virus (HEV): Molecular Cloning And Sequencing Of The Full-Length Viral Genome," Virology, 185:120-131 (1992).
Goldsmith et al., "Enzyme-Linked Immunosorbent Assay For Diagnosis Of Acute Sporadic Heptatis E In Egyptian Children," Lancet, 339:328-331 (1992).
Fry et al., "Hepatitis E Virus (HEV): Strain Variation In The Nonstructural Gene Region Encoding Consensus Motifs For An RNA-Dependent RNA Polymerase And An ATP/GTP Binding Site," Virus Genes, 6:173-185 (1992).
He, J. et al., "Expression and Diagnostic Utility of Hepatitis E Virus Putative Structural Proteins Expressed in Insect Cells," J. Clin. Micro., 31:2167-2173 (1993).
Bryan J.P. et al., "Epidemic Hepatitis E In Pakistan: Patterns of Serologic Response and Evidence that Antibody to Hepatitis E Virus Protects Against Disease," J. Infect. Dis., 170:517-21 (1994).
Purdy M.A. et al., "Preliminary Evidence that a trpE-HEV Fusion Protein Protects Cynomolgus Macaques Against Challenge With Wild-Type Hepatitis E Virus (HEV)," J. Med. Virology, 41:90-94 (1993).
Tsarev S.A. et al., "Elisa for Antibody to Hepatitis E Virus (HEV) Based On Complete Open-Reading Frame-2 Protein Expressed in Insect Cells: Identification of HEV Infection in Primates," J. Infect. DIs., 168:369-78 (1993).
Li, F. et al. Persistent and Transient Antibody Responses to Hepatitis E Virus Detected by Western Immunoblot Using Open Reading Frame 2 and 3 and Glutathione S-Transferase Fusion Proteins J. Clin. Microbiol, 32:2060-66 (1994).
Tsarev, S. et al., Variation In Course Of Hepatitis E In Experimentally Infected Cynomolgus Monkeys (1993) J. Infect. Dis., 167:1302-1306.
Tsarev, S. et al., Infectivity Titration Of A Prototype Strain Of Hepatitis E Virus Cynomolgus Monkeys (1994) J. Med. Virol., 43:135-142.
Carl et al, "Expression of Hepatitis E Virus Putative Structural Proteins in Recombinant Vaccinia Viruses," Clinical and Diagnostic Laboratory Immunology, 1:253-256 (1994).
Reyes et al. (1991) Gastroenterologia Japonica, 26:142-147.
Reyes et al. (1991) "Hepatitis E Virus (HEV): Epitope Mapping and Detection of Strain Variation", Elsevier Science Publisher Shikata et al. eds., Chapter 43:237-245.
Mast E. et al. (1996) Ann Rev. Med., 47:259-266.
Salynn Boyles (1995) Vaccine Weekly.
Tsarev, S.A. et al., "Prospects for Prevention of Hepatitis E" In Enterically Transmitted Hepatitis Viruses, Y. Buisson et al. eds. (1996) (La Simarre, Joue-les Tours (France) pp. 373-383.
McAtee, C.P. et al., (1996) Protein Expression and Purification, 8:262-270.
He, J. et al. (1995) J. Clin. Microbiol, 33:3308-3311.
Yin et al. (1994) A New Chinese Isolate of Hepatitis E Virus: Comparison with Strains Recovered from Different Geographical Regions, Virus Genes 9:1, 22-32.
Zhang et al. Expression, Characterization, and immunoreactivites of a Soluble Hepatits E Virus Putative Capsid Protein Species Expressed in Insect Cells, Clin. and Diag. Lab. Immunol., Jul. 1997, p. 423-428.
Emerson Suzanne U.
Purcell Robert H.
Robinson Robin A.
Tsarev Sergei A.
Eisenschenk Frank C.
Novavax Inc.
The United States of America as represented by the Department of
Zeman Mary K.
LandOfFree
Recombinant proteins of a pakistani strain of hepatitis E and th does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant proteins of a pakistani strain of hepatitis E and th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant proteins of a pakistani strain of hepatitis E and th will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-994319