Recombinant protein production in bovine adenovirus expression v

Details Recombinant protein production in bovine adenovirus expression v Recombinant protein production in bovine adenovirus expression v

1993-12-09

1998-10-13

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4352351, 4353201, 935 32, 935 65, 4242331, A61K 39235, C12N 701, C12N 1500

Patent

active

058208682

ABSTRACT:
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.

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