Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-08-16
1997-06-10
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4351723, 435 692, 435 693, 435 694, 435 695, 435 6951, 435 6952, 435 696, 435 697, 536 231, 935 33, 935 34, 935 60, 935 66, 935 70, C12P 2100, C12N 510
Patent
active
056374771
ABSTRACT:
A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear conditions. A metabolically transformed insect cell line is produced using the culture procedure regardless of genetic transformation. The recombinant polypeptide can be produced by an alternative process using virully infected or stably transformed insect cells containing a gene encoding the described polypeptide. The insect cells can also be a host for viral production.
REFERENCES:
patent: 4804628 (1989-02-01), Cracauer et al.
patent: 4988623 (1991-01-01), Schwarz et al.
patent: 5024947 (1991-06-01), Inlow et al.
patent: 5077214 (1991-12-01), Guarino et al.
patent: 5081035 (1992-01-01), Halberstadt et al.
patent: 5122469 (1992-06-01), Mather et al.
patent: 5153131 (1992-10-01), Wolf et al.
"Spin Filter Perfusion System for High Density Cell Culture: Production of Recombinant Urinary Type Plasminogen Activator in CHO Cells," Avegerinos, G.C., Drapeau, D., Socolow, J.S., Mao, J.-I., Hsiao, K., and Broeze, R.J., Biotechnology, 8, 54-58 (1990).
"Three-Dimensional Growth and Differentiation of Ovarian Tumor Cell Line in High Aspect Rotating-Wall Vessel: Morphologic and Embryologic Considerations," Becker, J.L., Prewett, T.L., Spaulding, G.F., and Goodwin, T.J., J. Cell Biochem., 51, 283-289 (1993).
"Protein Synthesis Requires Cell-Surface Contact while Nuclear Events Respond to Cell Chape in Anchorage-Dependent Fibroblasts," Ben-Ze'ev, A., Farmer, S.R., and Penman, S. Cell., 21, 365-372 (1980).
Cavegn, C., Young, J., Bertrand, M., and Bernard, A.R., "Animal Cell Technology: Products of Today, Prospects for Tomorrow," Spier, R.E., Griffiths, J.B., and Berthold, W., Eds., European Society for Animal Cell Technology (Butterworth-Heinemann, Oxford, 1994, pp. 43-49).
"Microscopic Visualization of Insect Cell-Bubble Interactions II: The Bubble Film and Bubble Rupture," Chalmers, J.J. and Bavarian, F. Biotechnol. Prog., 7, 151-158 (1991).
"Modification of Radiotherapy by Radiosensitizers and Cancer Chemotherapy Agents. I., Radiosensitizers," Coleman, C.N. Semin. Oncol., 16, 169-175 (1989).
"Polybrene-Mediated Transfection of Cultured Lepidopteran Cells: Induction of a Drosophila Heat Shock Promoter," Helgen, J.C. and Fallon, A.M., In Vitro Cell Dev. Biol., 26, 731-736 (1990).
Hugler, W., "Protein Expression of Sf9 Cells Under Stress and Simulated Microgravity," Thesis, Tulane University (1994), Title page, p. 11, pp. 29-35, 59, and 63-65.
"Use of Early Baculovirus Promoters for Continuous Expression and Efficient Processing of Foreign Gene Products in Stably Transformed Lepidopteran Cells," Jarvis, D.L., Fleming J.-A.G.W., Kovacs, G.R., Summers, M.D., and Guarino, L.A., Biotechnology, 8, 950-955 (1990).
"Culture of Insect Cells in a Helical Ribbon Impeller Bioreactor," Kamen, A.A., Tom, R.L., Caron, A.W., Chavarie, C., Massie, B., and Archambault, J., Biotechnol. Bioeng., 38, 619-628 (1991).
"Growth of Baculovirus-Infected Insect Cells in Microcapsules to a High Cell and Virus Density," King, G.A., Daugulis, A.J., Faulkner, P., Bayly, D., and Goosen, M.F.A., Biotechnol. Lett., 10, 683 687 (1988).
"Effects of Oxygen on Recombinant Protein Production by Suspension Cultures of Spodoptera frugiperda (Sf-9) Insect Cells," Scott, R.I., Blanchard, J.H., and Ferguson, C.H.R., Enzyme Microb. Technol., 14, 798-804 (1992).
"Effects of Oxygen/Glucose/Glutamine Feeding on Insect Cell Baculovirus Protein Expression: A Study on Epoxide Hydrolase Production," Wang, M.Y., Kwong, S., and Bentley, W.E. Biotechnol. Prog.,9, 355-361 (1993).
"Biopharmaceuticals Overcoming Market Hurdles," Thayer, A.M., C & EN, Feb. 25, 27-48 (1991).
"Enhanced Myocardial Salvage by Maintenance of Microvascular Patency Following Initial Thrombolysis with Recombinant Tissue Plasminogen Activator," Longridge, D.J., Follenfant, M.J., Maxwell, M.P., Ford, A.J., and Hughes B., Cardiovasc. Res., 24, 697-706 (1990).
"Treatment of the Anemia of Progressive Renal Failure with Recombinant Human Erthropoietin," Eschbach, J.W., Kelly, M.R., Haley, N.R., Abels, R.I., and Adamson, J.W., N. Engl. J. Med., 321, 158-162 (1989).
"Treatment of Sickle Cell Anemia with Hydroxyurea and Erthropoietin," Goldberg, M.A., Brugnara, C., Dover, G.J., Schapira, L., Charache, S., and Bunn, H.F., N. Engl. J. Med., 323, 366-372 (1990).
"Prevalence and Pathologic Features of Sickle Cell Nephropathy and Response to Inhibition of Angiotensin-Converting Enzyme," Falk, R.J., Scheinman, J., Phillips, G., Orringer, E., Johnson, A., and Jennette, J.C., N. Engl. J. Med., 326, 910-915 (1992).
"Ketoconazole an Inhibitor of the Cytochrome P-450 Dependent Testosterone Biosynthesis," Bossche, H.V., Lauwers W., Willemsens, G., Cools, W., Prog. Clin. Biol. Res., 185A, 187-196 (1985).
"Expression Systems for Heterologous Protein Production," Marino, M.H., BioPharm, Jul./Aug., 18-33 (1989).
"The Expression of Recombinant DNA Products in Mammalian Cells," Bebbington, C. and Hentschel, C., Trends Biotechnol., 3, 314-317 (1985).
"Concentrating Mammalian Cells I. Large-Scale Animal Cell Culture," Merten, O.W., Trends Biotechnol., 5,230-238 (1987).
"Industrial-Scale Mammalian Cell Culture, Part 1: Bioreactor Design Considerations," Nelson, K.L., BioPharm., Feb., 42-46 (1988).
"Bubble-Column Design for Growth of Fragile Insect Cells," Tramper, J., Smit, D., Straatman, J., and Vlak, J.M., Bioprocess Eng., 3,37-41 (1988).
"Manufacturing Steps in Animal Cell-Derived Biopharamaceutical Production," Rhodes, M., Genetic Engineering News, 10, Mar., 7 (1990).
"Industrial-Scale Mammalian Cell Culture, Part II: Design and Scale-Up," Nelson, K.L., BioPharm., Mar., 34-50 (1988).
"Agitation Effects on Microcarrier and Suspension CHO Cells," O'Connor, K. C. and Papoutsakis, E. T., Biotechnol. Tech., 6, 323-328 (1992).
"Damage Mechanisms of Suspended Animal Cells in Agitated Bioreactors with and Without Bubble Entrainment," Kunas, K.T. and Papoutsakis, E. T., Biotechnol. Bioeng., 36, 476-483 (1990).
"Hydrodynamic Effects on Cells in Agitated Tissue Culture Reactors," Cherry, R.S. and Papoutsakis, E. T., Bioprocess Eng., 1, 29-41 (1986).
"Hydrodynamic Effects on Animal Cells Grown in Microcarrier Cultures," Croughan, M.S., Hamel, J.F., and Wang, D.I.C., Biotechnol. Bioeng., 29, 130-141 (1987).
"Flow Effects on the Viability and Lysis of Suspended Mammalian Cells," McQueen, A., Meilhoc, E., and Bailey, J.E., Biotechnol. Letters, 9, 831-836 (1987).
"Reduced Erythrocyte Deformability Associated with Calcium Accululation," O'Rear, E. A., Udden, M. M., McIntire, L. V., and Lynch E. C., Biochim. Biophys. Acta, 691, 274-280 (1982).
"Effect of Flow on Polymorphonuclear Leukocyte/Endothelial Cell Adhesion," Lawrence, M.B., McIntire, L. V., and Eskin, S. G., Blood, 70, 1284-1290 (1987).
"Mechanical Effects on Endothelial Cell Morphology: In Vitro Assessment," Ives, C. L., Eskin, S. G., and McIntire, L. V., In Vitro Cell. Dev. Biol. 22, 500-507 (1986).
"Tissue Plasminogen Activator Messenger RNA Levels Increase in Cultured Human Endothelial Cells Exposed to Laminar Shear Stress," Diamond, S.L., Sharefkin, J.B., Dieffenbach, C., Frasier-Scott, D., McIntire, L. V., and Eskin, S. G., J. Cell. Physiol., 143, 364-371 (1990).
"Micropipette Aspiration of Cultured Bovine Aortic Endothelial Cells Exposed to Shear Stress," Sato, M., Levesque, M. J., and Nerem, R. M., Arteriosclerosis, 7, 276-286 (1987).
"Growth and Death in Overagitated Microcarrier Cell Cultures," Croughan, M.S., Hamel, J.F., and Wang, D. I. C., Biotechnol. Bioeng., 33, 731-744 (1989).
"Shear Sensitivity of Cultured Hybridoma Cells (CRL-8018) Depends on Mode of Growth, Culture Age and Metabolite Concentration," Petersen, J.F., McIntire, L. V., and Papoutsakis, E. T., J. Biotechnol., 7, 229-246 (1988).
"Expression of Human Plasminogen cDNA in a Baculovirus Vector-Infected Insect Cell System," Whitefleet-Smith, J., Rosen, E., McLinden, J., Ploplis, V. A., Fraser, M. J., Tomlinson, J. E., McLean, J. W., and Castellino, F.J., Arch. Biochem. Biophys., 271, 390-399 (
Andrews Angela D.
Francis Karen M.
Goodwin Thomas J.
O'Connor Kim C.
Prewett Tacey L.
Cate James M.
Low Christopher S. F.
The United States of America as respresented by the Administrato
LandOfFree
Recombinant protein production and insect cell culture and proce does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant protein production and insect cell culture and proce, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant protein production and insect cell culture and proce will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-763971