Recombinant protein production

Details Recombinant protein production Recombinant protein production

1993-10-01

1996-11-19

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352401, 43524031, 530383, 935 34, C07K 14755, C12N 502, C12N 510, C12N 1512

Patent

active

055761941

ABSTRACT:
Recombinant Factor VIII production is increased by supplementing the serum-free culture of mammalian host cells containing the gene therefor in a serum-free nutrient media with lipoprotein obtained from a mammalian source, preferably low density human lipoprotein or total bovine lipoprotein.

REFERENCES:
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Maciag et al Cell Bio International Reports, vol. 4, No. 1 Jan. 1980 pp. 43-50.
Kato et al J. Cellular Physiology vol. 120, pp. 354-363 (1984).
Schormuller, J. Lehrbuch der Lebensmittelchemie Springer-Verlag Berlin-Heidelberg, 1977 pp. 378-379.
Dorlington et al Somatic Cell Genetics vol. 8 pp. 403-412 (1982).
Miles Diagnostics Excyte Product Literature (1986).

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