Recombinant protein containing a C-terminal fragment of...

Details Recombinant protein containing a C-terminal fragment of... Recombinant protein containing a C-terminal fragment of...

2005-10-25

2005-10-25

Chin, Christopher L. (Department: 1641)

Chemistry: molecular biology and microbiology

Vector, per se

C424S191100, C424S272100, C435S069300, C435S069700, C435S069800, C435S071100, C435S235100, C435S348000, C536S023100, C536S023400, C536S023500, C536S023700, C536S024100

Reexamination Certificate

active

06958235

ABSTRACT:
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of thePlasmodiumtype, particularlyPlasmodium falciparum,which is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.

REFERENCES:
patent: 6096304 (2000-08-01), McCutchen
patent: 0621337 (1994-10-01), None
patent: 93/17107 (1993-09-01), None
Longacre et al., 1994, Plasmodium vivax merozoite surface protein 1 C-terminal recombinant proteins in baculovirus. Molecular and Biochemical Parasitology 64: 191-205.
Chappel et al., 1993. Monoclonal antibodies that inhibitPlasmodium falciparuminvasion in vitro recognise the lfirst growth factor-like domain of merozoite surface protein-1. Molecular and Biochemical Parasitology 60: 303-311.
Chang et al., 1992. A carboxyl-terminal fragment ofPlasmodium falciparumgp 195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth. Journal of Immunology 149: 548-555.
Miller et a.., 1993, Analysis of sequence diversity in thePlasmodium falciparummerozoite surface protein-1 (MSP-1). Molecular and Biochemical Parasitology 59: 1-14.

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