Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-08-28
2007-08-28
Helms, Larry R. (Department: 1643)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S007100, C435S070210, C530S387100
Reexamination Certificate
active
11039767
ABSTRACT:
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
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Bout Abraham
Brus Ronald Hendrik Pieter
Logtenberg Ton
Van Berkel Patrick Hendrikus Cornelis
Crucell Holland B.V.
Gussow Anne M.
Helms Larry R.
TraskBritt
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