Recombinant poxviruses with foreign DNA in essential regions

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

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4242041, 4242341, 4242691, 4242741, 4352351, 4353201, A61K 39285, A61K 39275, A61K 39002, A61K 3902, A61K 3912

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057702128

ABSTRACT:
Defective poxviruses that lack a function imparted by an essential region of its parental poxvirus are provided for protein production and vaccination. A DNA polynucleotide encoding a protein is inserted into the defective poxvirus and placed under transcriptional control of a promoter. The defective poxvirus is viable when the lost function of the essential region is complemented by a host cell, transgenic animal or helper virus.

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