Recombinant poxvirus host range selection system

Details Recombinant poxvirus host range selection system Recombinant poxvirus host range selection system

1992-06-23

1993-07-06

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352351, 4353201, 424 89, 424 88, C12P 2100, C12N 701, A61K 3900, A61K 3912

Patent

active

052253368

ABSTRACT:
What is described is a modified recombinant virus for expressing a gene product in a host. The modified recombinant virus has host range genes deleted therefrom so that the virus has restricted replication in the host. The modified recombinant virus also contains DNA which codes for and expresses the gene product in the host even with restricted replication of the virus in the host. The modified recombinant virus is used in a method for expressing a gene product in a host or in a cell cultured in vitro, and in a vaccine for inducing an immunological response in a host inoculated with the vaccine. What is also described is a selection system for the cloning and expression of open reading frames in poxviruses, particularly vaccinia virus. The selection system is based on a con

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