Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2008-01-15
2008-01-15
Parkin, Jeffrey S. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S202100, C424S208100, C536S023720
Reexamination Certificate
active
10469256
ABSTRACT:
The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary T cells, which are presented by a wide range of antigens of type Major Histocompatibility Complex (HLA-I). Recombinant poxviruses are obtained from said genes, which are useful for prophylactic and therapeutic vaccination against HIV/AIDS infections, are capable of generating a protective immune cell response in vaccinated laboratory animals and are recognized by the CTL lymphocytes of HIV/AIDS patients.
REFERENCES:
patent: 5174993 (1992-12-01), Paoletti
patent: 5505941 (1996-04-01), Paoletti
patent: 0412766 (1991-02-01), None
patent: WO9821354 (1998-05-01), None
Capsoni, F., et al., 1992, Membrane expression and function of complement receptors CR1 and CR3 on neutrophils from HIV-infected subjects: modulation by rTNF-alpha and rGM-CSF, Scand. J. Immunol. 36(4):541-546 (abstract provided).
Parker, S. F., et al., 1997, Distinct domains of adenovirus EIA interact with specific cellular factors to differentially modulate human immunodeficiency virus transcription, J. Virol. 71(3):2004-2012.
Manuel, L., et al., 2006, Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p. 75, J. Mol. Biol. 360(4):760-773.
Hanke Tomas et al., “Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitone Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen”,Journal of Virology, vol. 73, No. 9, pp. 7524-7532 (1999).
Duarte Carlos A. et al., “Epitope Mapping, V-Region DNA Sequence, and Neutralizing Fab Fragments of Two Monoclonal antibodies Against the HIV-1 V3 Loop”,Immunotechnology(Amsterdam), vol. 2, No. 1, pp. 11-20 (1996).
Whitton J. Lindsay et al., “A “String-of-Beads” Vaccine, Comprising Linked Minigenes, Confers Protection from Lethal Dose Virus Challenge”,Journal of Virology, vol. 67, No. 1, pp. 348-352 (1993).
Blomquist Dania M. Vazquez
Cano Carlos A. Duarte
Iglesias Perez Enrique
Centro de Ingenieria Genetica y Biotecnologia
Hoffman & Baron LLP
Parkin Jeffrey S.
LandOfFree
Recombinant poxvirus for chimeric proteins of the human... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant poxvirus for chimeric proteins of the human..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant poxvirus for chimeric proteins of the human... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3928421