Recombinant poxvirus-cytomegalovirus, compositions and uses

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

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4242301, 4242321, 435235, 435 693, 435 691, 4353201, A61K 39245, A61K 39285, C12N 1500, C12N 701

Patent

active

059978783

ABSTRACT:
Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA of the recombinant viruses can be used as probes or for generating PCR primers.

REFERENCES:
patent: 5494807 (1996-02-01), Paoletti et al.
Gehrz et al, 1992, Antivival Rej., vol. 17, pp. 115-131.
Tartaglia et al, 1992, Virology, vol. 188, pp. 217-232.
Perkus et al, 1985, Science, vol. 229, pp. 981-984.
Qadri et al, 1992, J. Gen. Virology, vol. 73, pp. 2913-2921.

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