Recombinant poxvirus-calicivirus rabbit hemorrhagic disease viru

Details Recombinant poxvirus-calicivirus rabbit hemorrhagic disease viru Recombinant poxvirus-calicivirus rabbit hemorrhagic disease viru

1995-06-06

1999-11-23

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4242041, 4352351, 4353201, 435325, 435 691, 536 2431, 536 2433, 536 2372, A61K 39285, C12N 1580, C12N 701

Patent

active

059895616

ABSTRACT:
Attenuated recombinant viruses containing DNA encoding a calicivirus antigen such as a RHDV antigen, e.g., a capsid gene, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA from the viruses can be used for probes or for primers.

REFERENCES:
patent: 5021347 (1991-06-01), Yasui et al.
patent: 5494807 (1996-02-01), Paoletti
Guiver et al. 1992, J. of Virology, vol. 73, pp. 2429-2433.
Buller et al. 1985, Nature, vol. 317 (6040), pp. 813-815.
Meyers et al. 1991, Virology, vol. 184, pp. 664-676.
Tartajlia et al, 1992, Virol., vol. 188, pp. 217-232.
Boga et al, 1994, J. Gen. Virol., vol. 75, pp. 2409-2413.
Laurent et al, 1994, J. Virol., pp. 6794-6798.
Negesha et al, 1995, Arch. Virol., vol. 140, pp. 1095-1108.

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