Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2006-10-10
2006-10-10
Whiteman, Brian (Department: 1635)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C435S320100
Reexamination Certificate
active
07118738
ABSTRACT:
Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e.g., to prevent establishment of tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MCU1 positive tumor cells.
REFERENCES:
patent: 5942235 (1999-08-01), Paoletti
patent: WO 95 03825 (1995-02-01), None
patent: WO 96 10419 (1996-04-01), None
patent: WO 97 40182 (1997-10-01), None
Scholl et al. Journal of Immunotherapy 23:570-580, 2000.
Bronte et al. Journal of Immunology 154:5282-5292, 1995.
Gunaburg et al. Molecular Medicine Today 1:410-417, 1995.
Acres RB et al. Journal of Immunotherapy 14:136-143, 1993.
Akagi, J. et al., J. Immunother. 20: 38-47 (1997).
Balloul, J.-M. et al., Cell. Mol. Biol. 40 (Sup.1): 49-59 (1994).
Bizouarne, N. et al., Breast Cancer Advances in Biology and Therapeutics; F. Calvo, M. Crepin, H. Magdelenat, eds.; John Liberty Eurotext, vol. 21: 308-8 (1996).
Graham, R.A. et al., Cancer Immunol. Immunther. 42: 71-80 (1996).
Taylor-Papadimitriou, J and Epenetos, A., Tibtech 12: 227-33 (1994).
Gritz Linda
Kantor Judith
Kufe Donald
Panicali Dennis
Schlom Jeffrey
Dana-Farber Cancer Institute
Nixon & Peabody LLP
The United States of America as represented by the Department of
Therion Biologics Corporation
Whiteman Brian
LandOfFree
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