Recombinant plasmid inserted with herpes simplex virus gene

Details Recombinant plasmid inserted with herpes simplex virus gene Recombinant plasmid inserted with herpes simplex virus gene

1986-08-15

1991-10-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Vector, per se

435942, 935 18, C12N 1581, C12N 1538

Patent

active

050595385

ABSTRACT:
A novel recombinant plasmid inserted with a herpes simplex virus gene, which comprises a plasmid vector containing a yeast DNA sequence and an Escherichia coli DNA sequence and carrying a promoter region and a herpes simplex virus gN gene (HSVgB) gene) recombined thereto under control of the promoter, said HSVgB gene lacking an N-terminal portion of the gene including a signal sequence-encoding region and optionally further lacking the region downstream therefrom, such as a gB gene lacking a DNA sequence encoding the N-terminal 30 amino acids, and a gB gene lacking a DNA sequence encoding the N-terminal 83 amino acids. The recombinant plasmid is useful for the production of transformed yeast, which is useful for the production of HSVgB proteins suitable for producing HSV vaccine and diagnostic reagents for herpes simplex virus infections.

REFERENCES:
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patent: 4661454 (1987-04-01), Botstein et al.
patent: 4738926 (1988-04-01), Hamada et al.
patent: 4745062 (1988-04-01), Guerineau et al.
Nakamura et al., Gene, 50 (1986) 239-245.
Izumoto et al. Gene, 59(1987) 151-159.
Molecular and Cell Biology of Yeasts, Ed. E. F. Walton et al., pp. 107, 1 114.
Principles of Gene Manipulation, an Introduction to Genetic Engineering, Ed. Old et al. (1981), p. 163.
Bzik et al., "Nucleotide Sequence Specifying the Glycoprotein Gene, gB, of Herpes Simplex Virus Type 1", Virology, vol. 133, 1984, pp. 301-314.
Cappel et al., "Immune Response to a DNA Free Herpes Simplex Vaccine in Man", Archives of Virology, vol. 73, 1982, pp. 61-67.

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