Recombinant phospholipase A.sub.2 enzyme

Details Recombinant phospholipase A.sub.2 enzyme Recombinant phospholipase A.sub.2 enzyme

1994-06-22

1997-01-14

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

536 232, C12N 920, C12N 1555

Patent

active

055938787

ABSTRACT:
The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.

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