Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-01-19
1998-06-16
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241991, 4353201, 435 693, 4352351, A61K 3912, C12P 2100, C12N 701, C12N 1500
Patent
active
057666024
ABSTRACT:
The present invention is directed toward a recombinant virus particle vaccine comprising a recombinant molecule packaged in an alphavirus coat. A preferred recombinant molecule of the present invention comprises a nucleic acid sequence that encodes a protective compound (e.g. a protective protein or a protective RNA) capable of protecting an animal from a disease, such that the nucleic acid sequence is operatively linked to a packaging-defective alphavirus expression vector that is capable of directing replication and transcription of the recombinant molecule. The invention also includes methods to produce and use such vaccines to protect animals from disease, particularly from disease caused by protozoan parasites such as Toxoplasma gondii, helminth parasites, ectoparasites, fungi, bacteria, or viruses.
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Grieve Robert B.
Xiong Cheng
Achutamurthy Ponnathapura
Bui Phuong T.
Heska Corporation
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