Recombinant oligometric protein complexes with enhanced...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide

Reexamination Certificate

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C424S196110, C424S209100, C424S210100, C530S350000, C536S023400, C536S023720, C435S320100, C435S325000, C435S252300

Reexamination Certificate

active

07449188

ABSTRACT:
The present invention relates to a chimeric protein comprising an antigen and an oligomerisation domain. The present invention relates further to recombinant oligomeric protein complexes comprising said chimeric protein and the use thereof for the manufacture of a vaccine.

REFERENCES:
patent: 5463024 (1995-10-01), Kingsman et al.
patent: 5721340 (1998-02-01), Halazonetis
patent: 7229624 (2007-06-01), Renner et al.
patent: WO 94/10308 (1994-05-01), None
patent: WO 99/62953 (1999-12-01), None
patent: WO 00/32227 (2000-06-01), None
patent: WO 0069907 (2000-11-01), None
patent: WO 01/02440 (2001-01-01), None
patent: WO 01/49886 (2001-07-01), None
patent: WO 01/49886 (2001-07-01), None
patent: WO 01/59886 (2001-07-01), None
Chang, C. et al., Phenotype mixing between different hepadnavirus nucleocapsid proteins revels C protein dimerization to be cis preferential. J. Virol. Aug. 1994;68(8):5225-31.
Fields Virology, 3rdEd. edited by Fields, B.N. et al. Lippincott—Raven Publishers, Philadelphia, 1996, “Orthomyxoviridae:The Viruses and their Replication” pp. 1355 and 1362-1365.
Weissenhorn, W. et al. Assembly of a rod-shaped chimera of a trimeric GCN4 zipper and the HIV-1 gp41 ectodormain expressed inEscherichia coli. Proc Natl Acad Sci U S A. Jun. 10, 1997;94(12):6065-9.
Cooper et al., “Mapping of Conformational B Cell Epitopes within Alpha-Helical Coiled Coil Proteins,” Molecular Immunology, vol. 34, No. 6 (433-440)(1997).
Harbury et al., “A Switch Between Two-, Three-, and Four-Stranded Coiled Coils in GCN4 Leucine Zipper Mutants,” Science, vol. 262, pp. 1401-1407 (1993).
Landschulz et al., “The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins,” Science, vol. 240 pp. 1759-1763 (1988).
Bucher, D.J., et al., “A2(N2) Neuraminidase of the X-7 Influenza Virus Recombinant: Determination of Molecular Size and Subunit Composition of the Active Unit,”J Virol, 10:60-66 (1972).
Burton, D.R., “A Vaccine for HIV Type 1: The Antibody Perspective,”Proc. Natl. Acad. Sci. USA, 94:10018-10023 (1997).
Chang, Z., et al., “Mycobacterium Tuberculosis16-kDa Antigen (Hsp16.3) Functions as an Oligomeric Structure in Vitro to Supress Thermal Aggregation,”J Biol Chem, 271:7218-7223 (1996).
Bowie, J.U., et al., “A Method to Identify Protein Sequences that Fold into a Known Three-Dimensional Structure,”Science, 253:164-170 (1991).
Deroo, T., et al., “Recombinant Neuraminidase Vaccine Protects Against Lethal Influenza,”Vaccine, 14:561-569 (1996).
Kodihalli, S., et al., “Selection of a Single Amino Acid Substitution in the Hemagglutinin Molecule by Chicken Eggs Can Render Influenza A Virus (H3) Candidate Vaccine Ineffective,”J Virol, 69:4888-4897 (1995).
Lin, X.H., et al., “Deletion of the Carboxy-Terminus of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein B Does Not Affect Oligomerization, Heparin-Binding Activity, or its Ability to Protect Against HSV Challenge,”Arch Virol, 141:1153-1165 (1996).
Neirynck, S., et al., “A Universal Influenza A Vaccine Based on the Extracellular Domain of the M2 Protein,”Nature Medicine, 5:1157-1163 (1999).
Sanchez, J., et al., “Recombinant Cholera Toxin B Subunit and Gene Fusion Proteins for Oral Vaccination,”Res. Microbiol., 141:971-979 (1990).
Sugrue, R.J., et al., “Structural Characteristics of the M2 Protein of Influenza A Viruses: Evidence that It Forms A Tetrameric Channel,”Virology, 180:617-624 (1991).
Varghese, J.N., et al., “Structure of the Influenza Virus Glycoprotein Antigen Neuraminidase at 2.9 A Resolution”Nature, 303:35-40 (1983).
Ward, C.W., et al., “The Disulphide Bonds of an Asian Influenza Virus Neuraminidase,”FEBS Lett, 153:29-33 (1983).
Winkler, G., et al., “Evidence that the Mature Form of the Flavivirus Nonstructural Protein NS1 is a Dimer,”Virology, 162:187-196 (1988).

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