Recombinant nucleic acids for inhibiting HIV gene expression

Details Recombinant nucleic acids for inhibiting HIV gene expression Recombinant nucleic acids for inhibiting HIV gene expression

1993-06-07

1997-07-22

Guzo, David

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353201, 536 2372, 536 241, 536 245, C12N 1511, C12N 1563, C12N 1586, C07H 2104

Patent

active

056503067

ABSTRACT:
This invention provides recombinant nucleic acid molecules for enhanced expression of genes that inhibit HIV gene expression. Cells transfected with these recombinant nucleic acids exhibit prolonged cell life. This invention also provides methods of treating individuals infected with HIV by introducing into them the transfected cells of this invention.

REFERENCES:
Woffendin et al., "Nonviral and Viral Delivery of a Human Immunodeficiency Virus Protective Gene Into Primary Human T Cells", PNAS, vol. 91, Nov. 1994, pp. 11581-11585.
Malim, Michael H. and Cullen, Bryan R. "HIV-1 Structural Gene Expression Requires the Binding of Multiple Rev Monomers to the Viral RRE: Implications for HIV-1 Latency." Cell 65:241-248 (1991).
Malim, Michael H. et al. "Stable Expression of Transdominant Rev Protein in Human T Cells Inhibits Human Immunodeficiency Virus Replication." J. Exp. Med. 176:1197-1201 (1992).
Sullenger, Bruce A. et al. "Overexpression of TAR Sequences Renders Cells Resistant to Human Immunodeficiency Virus Replication." Cell 63:601-608 (1990).
Lin, Wen-chang and Culp, Lloyd, A. "Selectable Plasmid Vectors with Alternative and Ultrasensitive Histochemical Marker Genes." BioTechniques 11:344-351 (1991).
Malim, Michael H. et al. "Functional Dissection of the HIV-1 Rev Trans-Activator-Derivation of a Trans-Dominant Repressor of Rev Function." Cell 58:205-214 (1989).

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