Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2004-12-23
2010-11-30
Mondesi, Robert (Department: 1645)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093100, C424S093400, C424S234100, C424S235100, C424S184100, C424S225100, C424S277100, C435S252100, C435S252300, C435S320100, C435S440000, C435S441000, C435S443000, C536S023100, C536S023400, C536S023700
Reexamination Certificate
active
07842289
ABSTRACT:
The present invention provides recombinant nucleic acid molecules, expression cassettes, and vectors useful for expression of polypeptides, including heterologous polypeptides, such as antigens, in bacteria. Some of the recombinant nucleic acid molecules, expression cassettes and vectors comprise codon-optimized sequences encoding the polypeptides and/or signal peptides. Some of the recombinant nucleic acid molecules, expression cassettes, and expression vectors comprise sequences encoding non-Listerial and/or non-secA1 signal peptides for secretion of the polypeptides. The invention also provides bacteria comprising the nucleic acid molecules, expression cassettes, and expression vectors, as well as compositions such as vaccines comprising the bacteria. Methods of making and using the bacteria, recombinant nucleic acid molecules, and expression cassettes are also provided.
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Cook David N.
Dubensky, Jr. Thomas W.
Luckett, Jr. William S.
Portnoy Daniel A.
Aduro BioTech
Biotechnology Law Group
Mondesi Robert
Ogunbiyi Oluwatosin
Whittaker Michael A.
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