Recombinant Newcastle disease virus nucleoprotein mutant as...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S192100, C435S006120

Reexamination Certificate

active

07070789

ABSTRACT:
The present invention provides a NDV mutant that is suited as a marker vaccine strain. The NDV mutant is not able to express an immunodominant epitope of the nucleoprotein (NP).

REFERENCES:
patent: 6146642 (2000-11-01), Garcia-Sastre et al.
patent: 0 974 660 (2000-01-01), None
A. Romer-Oberdorfer et al: “Generation of recombinant lentogenic Newcastle disease virus from cDNA”; J. Gen. Virol., vol. 80, 1999, pp. 2987-2995.
S. Rautenschlein et al: “Embryo vaccination of turkeys against Newcastle disease infection with recomvinant fowlpox virus constructs containing interferons as adjuvants”; Vaccine, vol. 18, 2000 pp. 426-433; table 2-4.
A. Makkay et al: “Antibody detection based differential ELISA for NDV infected or vaccinated chickens versus NDV Hn subunit vaccinated chickens”; Veterinary Microbiology, vol. 66, 1999, pp. 209-222.
M. Ward et al: “Nucleotide sequence and vaccinia expression of the nucleoprotein of a highly virulaent nurtopic strain of Newcastle disease virus” Avian Diseases, vol. 44, 2000 pp. 34-44.

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