Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1998-09-14
2000-11-14
Park, Hankyel
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4241921, 4241991, 4242081, 536 234, 536 2372, 536 241, 536 242, A61K 3917, A61K 3900, A61K 3912, A61K 3921, C07H 2104
Patent
active
061466425
ABSTRACT:
This invention relates to genetically engineered Newcastle disease viruses and viral vectors which express heterologous genes or mutated Newcastle disease viral genes or a combination of viral genes derived from different strains of Newcastle disease virus. The invention relates to the construction and use of recombinant negative strand NDV viral RNA templates which may be used with viral RNA-directed RNA polymerase to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. In a specific embodiment of the invention, the heterologous gene product is a peptide or protein derived from the genome of a human immunodeficiency virus. The RNA templates of the present invention may be prepared by transcription of appropriate DNA sequences using a DNA-directed RNA polymerase such as bacteriophage T7, T3 or the SP6 polymerase.
REFERENCES:
patent: 5166057 (1992-11-01), Palese et al.
patent: 5716821 (1998-02-01), Wertz et al.
Fahey et al., Status of immune-based therapies in HIV infection and AIDS, in. exp. Immunol., vol. 88, pp. 1-5, especially p. 3, col. 2 to p. 4, column 1, Jan. 1992.
Collins et al., 1991, "Rescue of Synthetic Analogs of Respiratory Syncytial Virus Genomic RNA and Effect of Truncations and Mutations on the Expression of a Foreign Reporter Gene", Proc. Natl. Acad. Sci. USA 88:9663-9667.
Collins et al., 1996, "Parainfluenza Viruses", Fields Virology (Lippencott-Raven Publishers, Philadelphia) pp. 1205-1242.
De and Banerjee, 1985, "Requirements and Functions of Vesicular Stomatitis Virus L and NS Proteins in the Transcription Process In Vitro", Biochem. Biophys. Res. Comm. 126:40-49.
Dreher and Hall, 1988, "Mutational Analysis of the Sequence and Structural Requirements in Brome Mosaic Virus RNA for Minus Strand Promoter Activity", J. Mol. Biol. 201:31-40.
Dreher et al., 1984, "Mutant Viral RNAs Synthesized In Vitro Show Altered Aminoacylation and Replicase Template Activities", Nature 311:171-175.
Emerson and Yu, 1975, "Both NS and L Proteins Are Required for In Vitro RNA Synthesis by Vesicular Stomatitis Virus", J. Virol. 15:1348-1356.
Enami et al., 1990, "Introduction of Site-Specific Mutations into the Genome of Influenza Virus", Proc. Natl. Acad. Sci. USA 87:3802-3805.
Fahey, J. and Schooley, R., 1992, "Status of Immune-based Therapies in HIV Infection and AIDS" Clin. Exp. Immunol. 88:1-5.
Kaplan et al., 1985, "In Vitro Synthesis of Infectious Poliovirus RNA", Proc. Natl. Acad. Sci. USA 82:8424-8428.
Kato et al., "Initiation of Sendai Virus Multiplication from Transfected cDNA or RNA with Negative or Positive Sense", Genes Cells (1996) 1:569-579.
Krystal et al., "Expression of The Three Influenza Virus Polymerase Proteins in a Single Cell Allows Growth Complementation of Viral Mutants", 1986, Proc. Natl. Acad. Sci. USA 83:2709-2713.
Kunkel, 1985, "Rapid and Efficient Site-Specific Mutagenesis without Phenotypic Selection", Proc. Natl. Acad. Sci. USA 82:488.
Levis et al., 1986, "Deletion Mapping of Sindbis Virus DI RNAs Derived from cDNAs Defines the Sequences Essential for Replication and Packaging", Cell 44:137-45.
Luytjes et al., 1989, "Amplification, Expression, and Packaging of a Foreign Gene by Influenza Virus", Cell 59:1107-1113.
Naito and Ishihama, 1976, "Function and Structure of RNA Polymerase from Vesicular Stomatitis Virus", J. Biol. Chem. 251:4307-4314.
Nara et al., 1987, "Simple, Rapid, Quantitative, Syncytium-Forming Microassay for the Detection of Human Immunodeficiency Virus Neutralizing Antibody", AIDS Res. Hum. Retroviruses 3:283-302.
Park et al., 1991, Rescue of a Foreign Gene by Sendai Virus, Proc. Natl. Acad. Sci. USA 88:5537-5541.
Roberts, A and Rose, J., 1998, "Recovery of Negative-Strand RNA Virus from Plasmid DNAs: A Positive Approach Revitilizes a Negative Field", Virology 247:1-6.
Racaniello et al., 1981, "Cloned Poliovirus Complementary DNA is Infectious in Mammalian Cells", Science 214:916-919.
Schnell et al., 1994, "Infectious Rabies Viruses from Cloned cDNA", EMBO J. 13:4195-2033.
Szewczyk et al., 1988, "Purification, Thioredoxin Renaturation, and Reconstituted Activity of The Three Subunits of the Influenza A Virus RNA Polymerase", Proc. Natl. Acad. Sci. USA 85:7907-7911.
Taylor et al., 1990, "Newcastle Disease Virus Fusion Protein Expressed in a Fowlpox Virus Recombinant Confers Protection in Chickens", J. Virol. 64:1441-1450.
Yusoff K. et al., 1987, "Nucleotide Sequence Analysis of the L Gene of Newcastle Disease Virus: Homologies with Sendi and Vesicular Stomatitis Viruses" Nucleic Acids Res. 15: 3961-76.
Ward et al., 1988, "Direct Measurement of the Poliovirus RNA Polymerase Error Frequency In Vitro", J. Virol. 62:558-562.
Zaghouani et al., 1992, "Cells Expressing an H Chain Ig Gene Carrying a Viral T Cell Epitope Are Lysed by Specific Cytolytic T Cells", J. Immunol. 148:3604-3609.
Zaghouani et al., "Cells Expressing an H Chain Ig Gene Carrying a Viral T Cell Epitope Are Lysed by Specific Cytolytic T Cells", 1991, Proc. Natl. Acad. Sci. USA 88:5645-6549.
Garcia-Sastre Adolfo
Palese Peter
Mount Sinai School of Medicine, of the City University of New Yo
Park Hankyel
LandOfFree
Recombinant new castle disease virus RNA expression systems and does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant new castle disease virus RNA expression systems and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant new castle disease virus RNA expression systems and will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2062363