Recombinant nerve growth factor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352401, 4353201, 536 231, 530399, C12P 2106, C12N 508, C12N 1518, C07K 1448

Patent

active

056838948

ABSTRACT:
A method for producing pure, active, mature recombinant Nerve Growth Factor-beta is disclosed, as is the protein so produced.

REFERENCES:
Scott et al Nature vol. 302 pp. 538-540 1983 "Isolation and Nucleotide Sequence of a CDNA Encoding the Precursor of Nerve Growth Factor ".
Angeletti et al., Biochemistry (1973) 12:100-115.
Berger et al., Proc. Nat. Acad. Sci. (1977) 74:3647-3651.
Darling et al., "Cold Spring Harbor Symposia On Quantitative Biology " (1983) pp. 427-434.
Edwards et al., "Processing of the Native NGF Precursor to Form Biologically Active NGF" (unpublished).
Fischer et al., Nature (1987) 329:65-68.
Hofer et al., Nature (1988) 331:261-262.
Lindholm et al., Nature (1987) 330:658-659.
Saboori et al., Biochemistry (1986) 25:5565-5571.
Edwards et al., Nature (1986) 319:784-787.
Heijne, Nucleic Acids Res. (1986) 14:4683-4690.
Selby et al., Mol. Cell. Biol. (1987) 7:3057-3064.

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