Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-06
1998-10-13
Fleisher, Mindy
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4353201, 4242061, A61K 39145, C12N 1563
Patent
active
058208712
ABSTRACT:
Recombinant negative-strand viral RNA templates are described which may be sed with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. The RNA templates are prepared by transcription of appropriate DNA sequences with a DNA-directed RNA polymerase. The resulting RNA templates are of the negative-polarity and contain appropriate terminal sequences which enable the viral RNA-synthesizing apparatus to recognize the template. Bicistronic mRNAs can be constructed to permit internal initiation of translation of viral sequences and allow for the expression of foreign protein coding sequences from the regular terminal initiation site, or vice versa.
REFERENCES:
patent: 5166057 (1992-11-01), Palese et al.
Horvath et al, The EMBO Journal, 1990, vol. 9(8): pp. 2639-2647.
Macejak et al, Nature, Sep., 1991, vol. 353: pp. 90-94.
Garcia-Sastre Adolfo
Palese Peter
Fleisher Mindy
McKelvey Terry A.
The Mount Sinai School of Medicine of the City University of New
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