Recombinant negative strand RNA virus expression systems and vac

Details Recombinant negative strand RNA virus expression systems and vac Recombinant negative strand RNA virus expression systems and vac

1995-06-06

1998-10-13

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4353201, 4242061, A61K 39145, C12N 1563

Patent

active

058208712

ABSTRACT:
Recombinant negative-strand viral RNA templates are described which may be sed with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. The RNA templates are prepared by transcription of appropriate DNA sequences with a DNA-directed RNA polymerase. The resulting RNA templates are of the negative-polarity and contain appropriate terminal sequences which enable the viral RNA-synthesizing apparatus to recognize the template. Bicistronic mRNAs can be constructed to permit internal initiation of translation of viral sequences and allow for the expression of foreign protein coding sequences from the regular terminal initiation site, or vice versa.

REFERENCES:
patent: 5166057 (1992-11-01), Palese et al.
Horvath et al, The EMBO Journal, 1990, vol. 9(8): pp. 2639-2647.
Macejak et al, Nature, Sep., 1991, vol. 353: pp. 90-94.

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