Recombinant N-SMases and nucleic acids encoding same

Details Recombinant N-SMases and nucleic acids encoding same Recombinant N-SMases and nucleic acids encoding same

1996-12-24

1999-07-06

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 6, 4353201, 4352523, 43525411, 435325, 536 232, 536 234, 536 243, C12N 922, C12N 1500, C12N 120, C07H 2104

Patent

active

059196874

ABSTRACT:
Isolated nucleic acids are provided that encode human neutral sphingomyelinase (N-SMase) and N-SMase fragments and derivatives capable of hybridizing to such N-SMase-encoding nucleic acids. The invention also includes isolated recombinant human neutral sphingomyelinase (N-SMase) and N-SMase fragments and derivatives are also provided. Novel assays are also provided to identify compounds useful in the diagnosis or treatment of human neutral sphingomyelinase related disorders.

REFERENCES:
patent: 5451518 (1995-09-01), Kolesnick
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