Recombinant mycobacterial vaccines

Details Recombinant mycobacterial vaccines Recombinant mycobacterial vaccines

1995-06-05

1998-11-03

Elliott, George C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424 932, 424 934, 4242481, 4242821, 435 691, 4351723, 4352523, 4352531, 435863, 435864, 435865, 435866, A61K 3904, A61K 3921, C12N 121

Patent

active

058304754

ABSTRACT:
The present invention relates to recombinant mycobacteria, particularly recombinant M. bovis BCG, which express heterologous DNA encoding a product (protein or polypeptide) of interest, such a protein or polypeptide (e.g., an antigen) against which an immune response is desired, or a cytokine.

REFERENCES:
Labidi et al., FEMS Microbiol. Lett., 30:221--225 (1985).
Labidi et al., Ann. Inst. Pasteur Microbiol., 136 B(2):209-215 (1985).
Jacobs et al., Nature, 327:532-535 (1987).
Norgard et al., J. Bacteriol., 133(3): 1254-1262 (1978).
Burke et al., EMBO J., 3(11): 2549-2554 (1984).
Lindquist et al., Ann. Rev. Genet., 22: 631-677 (1988).
Lathigra et al., Nucl. Acids. Res., 16(4): 1636 (1988).
Thole et al., Infec. and Immun., 55(6): 1466-1475 (1987).

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