Recombinant MVA virus, and the use thereof

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

Reexamination Certificate

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C435S005000, C424S184100, C424S199100, C424S204100, C424S205100, C424S232100

Reexamination Certificate

active

10147284

ABSTRACT:
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the site of a naturally occurring deletion in the MVA genome, and the use of such recombinant MVA viruses for the production of polypeptides, e.g. antigens or therapeutic agents, or viral vectors for gene therapy, and the use of such recombinant MVA viruses encoding antigens as vaccines.

REFERENCES:
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Sutter, G., et al., “A Recombinant Vector Derived from the Host Range-Restricted and Highly Attenuated MVA Strain of Vaccinia Virus Stimulates Protective Immunity in Mice to Influenza Virus,”Vaccine, 12(11) :1032-1040 (1994).
Hirsch, V.M., et al., “Limited Virus Replication Following SIV Challenge of Macaques Immunized with Attenuated MVA Vaccinia Expressing SIVsmenvandgag-pol,” Vaccines 95,Cold Spring Harbor Laboratory Press, USA, pp. 195-200 (1995).
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Sutter, G. and Moss, B., “Novel Vaccinia Vector Derived from the Host Range Restricted and Highly Attenuated MVA Strain of Vaccinia Virus,”Dev. Biol. Stand. Basel, Karger, 84:195-200 (1995).
Altenburger, W., et al., “Partial Deletion of the Human Host Range Gene in the Attenuated Vaccinia Virus MVA,”Arch. Virol.,105:15-27 (1989).
Hirsch, V.M., et al., “Patterns of Viral Replication Correlate with Outcome in Simian Immunodeficiency Virus (SIV) -Infected Macaques: Effect of Prior Immunization with a Trivalent SIV Vaccine in Modified Vaccinia Virus Ankara,”J. Virol.,70(6) :3741-3752 (1996).
Wyatt, et al., “Replication-deficient vaccinia virus encoding bacteriophage T7 RNA polymerase for transient gene expression in mammalian cells”,Virol.,210:202-205 (1995).
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NTIS Accession No. PB89144802; “Novel Inhibitor of HIV Infection”.
NTIS Accession No. PB88201363, “Novel Recombinant Vaccinia Virus Expression Vectors and Method of Selecting Same”.
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Sutter, G., et al., “Non-Replicating Vaccinia Vector Efficiently Expresses Bacteriophage T7 RNA Polymerase,”FEBS Letters371:9-12 (1995).

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