Recombinant mutants for inducing specific immune responses

Details Recombinant mutants for inducing specific immune responses Recombinant mutants for inducing specific immune responses

1995-02-27

1999-08-10

Scheiner, Laurie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

4241841, 4241851, 4241901, 4242011, 4242531, 4242541, 4242341, 435 693, 514 2, 530350, 530825, A61K 3910, A61K 39295, C07K 14235

Patent

active

059355808

ABSTRACT:
This invention relates to a recombinant plasmid comprising the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella adenylate cyclase in a transformed host cell. This invention also relates to a recombinat DNA molecule comprising the Bordetella cyaA gene containing at least one insertion of a heterologous DNA sequence at at least one permissive site. This invention further relates to recombinant Bordetella adenylate cyclase comprising a heterologous epitope at a permissive site as well as methods of inducing a specific B cell, helper T cell, and CTL cell immune response.

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