Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Reexamination Certificate
2006-08-08
2006-08-08
Winkler, Ulrike (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
C424S201100, C424S202100, C424S221100, C424S232100, C435S069100, C435S069300, C435S235100, C435S252300, C435S320100
Reexamination Certificate
active
07087234
ABSTRACT:
The present invention relates to multivalent recombinant raccoon poxviruses, containing more than one exogenous gene inserted into either the thymidine kinase gene, the hemagglutinin gene, or a combination thereof. Disclosed is the use of the multivalent recombinant raccoon poxviruses as vaccines to immunize felines against subsequent challenge by feline pathogens. Also disclosed is a method of making a multivalent recombinant raccoon poxvirus by a recombination process involving the construction of an insertion vector into which the exogenous genes are inserted, and flanking the inserted genes are sequences which can recombine into the raccoon poxvirus thymidine kinase gene, or the hemagglutinin gene, or a combination thereof; introducing both the insertion vector containing the exogenous genes, and raccoon poxvirus into susceptible host cells; and selecting the recombinant raccoon poxvirus from the resultant plaques.
REFERENCES:
patent: 4971793 (1990-11-01), Wood et al.
patent: 5266313 (1993-11-01), Esposito et al.
patent: 5656275 (1997-08-01), Wasmoen et al.
patent: 5770211 (1998-06-01), Wasmoen et al.
patent: 5820869 (1998-10-01), Wasmoen et al.
patent: 5849303 (1998-12-01), Wasmoen et al.
patent: 6241989 (2001-06-01), Scott et al.
Hu et al., “Construction and Characterization of Raccoonpoxvirus (RCNV) Recombinant Expressing Feline Panleukopenia virus -vp2 (FPV), Rabies-G (RAB), and Feline Calicivirus (FCV) Capsid Proteins”; Abstract for ASV Meeting of Jul. 9-13, 1994.
Lodmell, et al., Raccoon Poxvirus Recombinants Expressing the Rabies Virus Nucleoprotein Protect Mice Against Lethal Rabies Virus Infection, Journal of Virology, Jun. 1991, pp. 3400-3405.
Parrish, et al., Canine Host Range and a Specific Epitope Map Along with Variant Sequences in the Capsid Protein Gene of Canine Parvovirus and Related Feline, Mink, and Raccoon Parvoviruses, Journal of Virology, 1988, 166:293-307.
Parrish, et al., Mapping Specific Functions in the Capsid Structure of Canine Parvovirus and Feline Panleukophenia Virus Using Infectious Plasmid Clones, Journal of Virology, 1991, 183:195-205.
Martyn, et al., Nucleotide Sequence of Feline Panleukopenia Virus: Comparison With Canine Parvovirus Identifies Host-Specific Differences, Journal of General Virology, 1990, 71:2747-2753.
Carlson, et al., Cloning and Sequence of DNA Encoding Structural Proteins of the Autonomous Parvovirus Feline Panleukopenia Virus, Journal of Virology, Sep. 1985, pp. 574-582.
Esposito, et al., Successful Oral Rabies Vaccination of Reccoons With Raccoon Poxvirus Recombinants Expressing Rabies Virus Glycoprotein, Journal of Virology, 1988, 165:313-316.
Vennema, et al., Primary Structure of the Membrane and Nucleocapsid Protein Genes of Feline Infectious Peritonitis Virus and Immunogenicity of Recombinant Vaccinia Viruses in Kittens, Journal of Virology, 1991, 181:327-335.
Falkner, et al.,Escherichia coligpt Gene Provides Dominant Selection for Vaccinia Virus Open Reading Frame Expression Vectors, Journal of Virology, Jun. 1988, vol. 62, No. 6, pp. 1849-1854.
Esposito Joseph J.
Hu Liangbiao
Ngichabe Christopher K.
Scott Fred W.
Cornell Research Foundation Inc.
Hodgson & Russ LLP
The United States of America as represented by the Department of
Winkler Ulrike
LandOfFree
Recombinant multivalent viral vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant multivalent viral vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant multivalent viral vaccine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3650442