Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2008-01-01
2008-01-01
Helms, Larry R. (Department: 1643)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S133100, C424S138100, C435S007230, C530S388300
Reexamination Certificate
active
07314622
ABSTRACT:
The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.
REFERENCES:
patent: 4810781 (1989-03-01), Hollinshead et al.
patent: 5431897 (1995-07-01), Welt et al.
patent: 5712369 (1998-01-01), Old et al.
patent: 5851526 (1998-12-01), Welt et al.
patent: 6190640 (2001-02-01), Welt et al.
patent: 6291235 (2001-09-01), Welt et al.
patent: 6307026 (2001-10-01), King et al.
patent: 6652853 (2003-11-01), Welt et al.
patent: 7125689 (2006-10-01), Carr et al.
patent: 2003/0031671 (2003-02-01), Welt et al.
patent: 2003/0040027 (2003-02-01), Ritter et al.
patent: 2007/0031327 (2007-02-01), Luzzi et al.
Burgess et al, Journal of Cell Biology vol. 111 Nov. 1990 2129-2138.
Lazar et al Molecular and Cellular Biology Mar. 1988 vol. 8 No. 3 1247-1252).
Schwartz et al, Proc Natl Acad Sci USA vol. 84:6408-6411 (1987).
Lin et al Biochemistry USA vol. 14:1559-1563 (1975).
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979).
Heath, J. K. et al., The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily,Proc. Natl. Acad. Sci. USA, 94(2):469-474, 1997.
Hollinshead, A.C. et al., Separation of skin reactive intestinal cancer antigen from the carcinoembryonic antigen of Gold,Science, 177(52):887-889, 1972.
Hollinshead, A. et al., Further comparison's of separated intestinal cancer, fetal intestinal and normal intestinal soluble membrane antigen and the role of tumor related antigens in the diagnosis and treatment of intestinal cancer, Proc.Second Intl. Symp. Cancer Detection and Prevention, Bologna, Italy, pp. 616-620, Apr. 1973.
Hollinshead, A. et al., Skin-reactive soluble antigen from intestinal cancer-cell-membranes and relationship to carcinoembryonic antigens,Lancet, 1(7658):1191-1195, 1970.
Hollinshead, A. et al., Specific active immunotherapy in patients with adenocarcinoma of the colon utilizing tumor-associated antigens (TAA). A phase I clinical trial,Cancer, 56:480-489, 1985.
Johnstone, C. N. et al., Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells,Am. J. Physiol. Gastrointest. Liver Physiol., 2000 279(3):G500-G510, 2000.
Kurihara, M. et al., Soluble membrane antigens of gastric cancer cells: an analysis and study of activity in inducing cell-mediated immune responses,J. Jap. Soc. Cancer Ther., 14(3):313-324, 1979.
Ritter, G. et al., Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium,Biochem. Biophys. Res. Commun., 236(3):682-686, 1997.
Ritter, G. et al., Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33,Cancer Res., 61:6851-6859, 2001.
Welt, S., Phase I study of anticolon cancer humanized antibody A33,Clin. Cancer Res., 9:1338-1346, 2003.
Arlen Myron
Bristol J. Andrew
Hollinshead Ariel C.
Tsang Kwong Y.
Bristol Lynn
Helms Larry R.
Neogenix Oncology, Inc.
Nixon & Peabody LLP
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