Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1991-06-07
2000-10-17
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 697, 435 699, 4352523, 43525231, 4353201, 530324, 536 234, 536 235, 514 12, 935 10, 935 28, 935 29, 935 69, 935 74, 935 48, A61K 3764, C12N 1511, C12N 1515, C12N 1579
Patent
active
061329908
ABSTRACT:
A synthetic DNA sequence and its genetic equivalents are disclosed which sequences are capable, when used in a recombinant DNA method, of directing production of a serine protease inibitor protein. Recombinant DNA methods for the production of serine protease inhibitor proteins are also disclosed. These methods incorporate either the synthetic DNA sequence of the present invention or natural DNA sequences isolated from human cDNA or genomic libraries.
In addition, a single polypeptide chain protein is disclosed which is capable of inhibiting chymotrypsin and elastase but not trypsin. In one embodiment, this protein is a shortened from (single domain) of the protein produced by the method described herein.
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Bandyopadhyay Pradip K.
Eisenberg Stephen P.
Stetler Gary L.
Thompson Robert C.
Amgen Boulder Inc.
Moore William W.
Wax Robert A.
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