Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1994-08-24
1997-07-22
Guzo, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4353201, A61K 39265, C12N 1586
Patent
active
056501536
ABSTRACT:
There is provided a recombinant Marek's disease virus comprising the genomic DNA of an attenuated Marek's disease virus and a foreign gene from another source. The present recombinant virus can advantageously be used as an active ingredient for a multifunctional live vaccine, exhibiting not only the antigenicity and immunogenicity of the Marek's disease virus but also the properties ascribed to the foreign gene. Since the suitable host cell for the recombinant virus of the present invention is an avian cell which is available in a large quantity and not expensive, the recombinant virus of the present invention can be produced efficiently at low cost on a commercial scale.
REFERENCES:
Van Zaane et al., "Molecular-Biological Characterization of Marek's Disease Virus", Virology, vol. 121, pp. 133-146, 1982.
Gibbs, Carol P. et al. "Extensive Homology Exitst Between Marek Disease Herpesvirus and Its Vaccine Virus, Herpesvirus of Turkeys." Proceedings of the National Academy of Sciences of The United States of America, vol. 81, No. 11(Jun. 1984), pp. 3365-3369.
Silva, Robert F. et al. "Genomic Expansion of Marek's Disease Virus DNA Is Associated with Serial In Vitro Passage." Journal of Virology, vol. 54, No. 3(Jun. 1985), pp. 690-696.
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Bio/Technology, vol. 6, pp. 47-55 (1988).
Journal of Virology, vol. 51, pp. 102-109 (1984).
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Virology, vol. 157, pp. 351-358 (1987).
Journal of Virology, vol. 61, pp. 2614-2620 (1987).
Fukai Konosuke
Ishikawa Toyokazu
Manabe Sadao
Mori Chisato
Osame Juichiro
Guzo David
The Research Foundation for Microbial Diseases
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