Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-07-29
1993-07-06
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530300, 424 88, C07K 1300, C07K 710, A61K 3900
Patent
active
052255344
ABSTRACT:
The invention provides polypeptides which correspond in at least one specific epitope with a plasmodium falciparum merozoite antigen having a molecular weight of about 41,000 Daltons, and a process for their production. The invention further provides immunogenic compositions which contain such a polypeptide and a suitable adjuvant, a DNA sequence which codes for such a polypeptide, replicable microbial vectors which contain such a DNA sequence, microorganisms which contain such a replicable vector and antibodies against a polypeptide of the invention. The invention still further provides processes for the production of the immunogenic compositions, the microorganisms and the antibodies and for the use of the polypeptides and the immunogenic compositions for the immunization of mammals against malaria.
REFERENCES:
Siddiqui et al. I & I 52:314-318 1986.
Del Guidice et al. J. of Imm. 137: 2952-2955 1986.
Perrin et al. J. Clin. Invest. 75:1718-172 1985 Immunization with a Plasmodium Falciparum Merozoite Surface Antigen Induces Partial Immunity in Monkeys.
Weber, et al., Nucleic Acids Res. 14:3311-3323 (1986).
Cheung, et al., EMBO J. 4:1007-1011 (1985).
McGarvey, et al., Proc. Natl. Acad. Sci. USA 81:3690-94 (1984).
Epstein William H.
Gould George M.
Hoffmann-La Roche Inc.
Nucker Christine M.
Roseman Catherine R.
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